Sudden cardiac arrest is the third leading cause of death in Europe. The annual incidence of OHCA in Europe is between 67 and 170 patients per 100,000 inhabitants, and the survival rates at hospital discharge are on average 8%. The annual incidence of IHCA in Europe is between 1,5 and 2,8 people per 1000 hospital admissions, while survival rates at 30 days/hospital discharge range from 15% to 34%. Basic life support puts emphasis on recognizing arest and starting resuscitation as early as possible and promotes early defibrillation using AED. All providers of CPR should carry out chest compressions, and those who are educated and capable should combine chest compressions with rescue breathing in a ratio of 30:2. Advanced life support prioritizes high-quality continuous chest compressions with minimal interruptions and early defibrillation using self-adhesive electrodes. Endotracheal intubation is the most advanced way to establish and maintain the airway. Wave capnography confirms and continuously monitors the position of the tube and the quality of CPR. Successful resuscitation leads to the establishment of the return of spontaneous circulation after prolonged ischemia of the entire body. Prolonged ischemia and reperfusion cause global damage to tissues and organs. Post-cardiac arrest syndrome (PCAS) is a combination of pathophysiological events after cardiac arest that include brain injury, myocardial dysfunction, systemic ischemic-reperfusion response and persistent precipitating pathology. Post-resuscitation care begins immediately after the return of spontaneous circulation is established, and treatment of post-cardiac arrest syndrome includes the management of multiple organic systems, optimization of oxygenation and ventilation, hemodynamic and metabolic variables, and targeted temperature control. The goal of the treatment is a complete neurological recovery, and the post-resuscitation prognosis is based on a multimodal approach that includes clinical examination, neurophysiological tests, measurement of serum biomarkers and neuroradiological methods. In addition to measuring the neurological outcome, problems that accompany patients after discharge from the hospital are essential, including cognitive, emotional and physical problems and fatigue. Accordingly, a functional assessments of physical, cognitive and emotional impairments is required before discharging the patient from the hospital and a follow-up within three months in order to identify the need for further rehabilitation.