prikaz prve stranice dokumenta Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
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Scientific paper - Original scientific paper
Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
Bosnian Journal of Basic Medical Sciences, 23 (2022), 1; 176-186. https://doi.org/10.17305/bjbms.2022.7497
Škara, Lucija; Vodopić, Tonći; Pezelj, Ivan; Abramović, Irena; Vrhovec, Borna; Vrtarić, Alen; Sinčić, Nino; Tomas, Davor; Bulimbašić, Stela; Kuliš, Tomislav; Ulamec, Monika

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Škara, L., Vodopić, T., Pezelj, I., Abramović, I., Vrhovec, B., Vrtarić, A. ... Ulamec, M. (2022). Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker. Bosnian Journal of Basic Medical Sciences, 23. (1), 176-186. doi: 10.17305/bjbms.2022.7497

Škara, Lucija, et al. "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker." Bosnian Journal of Basic Medical Sciences, vol. 23, no. 1, 2022, pp. 176-186. https://doi.org/10.17305/bjbms.2022.7497

Škara, Lucija, Tonći Vodopić, Ivan Pezelj, Irena Abramović, Borna Vrhovec, Alen Vrtarić, Nino Sinčić, et al. "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker." Bosnian Journal of Basic Medical Sciences 23, no. 1 (2022): 176-186. https://doi.org/10.17305/bjbms.2022.7497

Škara, L., et al. (2022) 'Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker', Bosnian Journal of Basic Medical Sciences, 23(1), pp. 176-186. doi: 10.17305/bjbms.2022.7497

Škara L, Vodopić T, Pezelj I, Abramović I, Vrhovec B, Vrtarić A, and sur.. Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker. Bosnian Journal of Basic Medical Sciences [Internet]. 2022 February 01 [cited 2024 November 04];23(1):176-186. doi: 10.17305/bjbms.2022.7497

L. Škara, et al., "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker", Bosnian Journal of Basic Medical Sciences, vol. 23, no. 1, pp. 176-186, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:191297. [Accessed: 04 November 2024]

Metadata
Title (english)Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
AuthorLucija Škara
AuthorTonći Vodopić
AuthorIvan Pezelj
AuthorIrena Abramović
AuthorBorna Vrhovec
AuthorAlen Vrtarić
AuthorNino Sinčić
AuthorDavor Tomas
AuthorStela Bulimbašić
AuthorTomislav Kuliš
AuthorMonika Ulamec
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
High prevalence and mortality of prostate cancer (PCa) are well known global health issues. Novel biomarkers for better identifying patients with PCa are the subject of extensive research. Prostate specific antigen (PSA) shows low specificity in screening and diagnostics, leading to unnecessary biopsies and health costs. Eighty patients with PCa and benign prostate hyperplasia (BPH) were included in the study. We analyzed CAV1 gene expression and methylation in tissue. CAV1 cfDNA methylation from blood and seminal plasma was accessed as a potential PCa biomarker. Although methylation in blood plasma did not differ between PCa and BPH patients, methylation in seminal plasma showed better PCa biomarker performances than tPSA (AUC 0.63 vs. AUC 0.52). Discrimination of BPH and Gleason grade group 1 PCa patients from patients with higher Gleason grade groups revealed very good performance as well (AUC 0.72). CAV1 methylation is useful biomarker with potential for further seminal plasma cfDNA research, but its diagnostic accuracy should be improved, as well as general knowledge about cfDNA in seminal plasma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 23, no. 1, pp. 176-186
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2022.7497
URN:NBNurn:nbn:hr:105:191297
Publication2022-02-01
Document URLhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/7497
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-01 16:36:11