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Scientific paper - Original scientific paper
The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C
Viruses, 14 (2022), 8; 1613. https://doi.org/10.3390/v14081613
Radmanić, Leona; Bodulić, Kristian; Šimičić, Petra; Vince, Adriana; Židovec Lepej, Snježana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Radmanić, L., Bodulić, K., Šimičić, P., Vince, A. & Židovec Lepej, S. (2022). The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C. Viruses, 14. (8). doi: 10.3390/v14081613

Radmanić, Leona, et al. "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C." Viruses, vol. 14, no. 8, 2022. https://doi.org/10.3390/v14081613

Radmanić, Leona, Kristian Bodulić, Petra Šimičić, Adriana Vince and Snježana Židovec Lepej. "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C." Viruses 14, no. 8 (2022). https://doi.org/10.3390/v14081613

Radmanić, L., et al. (2022) 'The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C', Viruses, 14(8). doi: 10.3390/v14081613

Radmanić L, Bodulić K, Šimičić P, Vince A, Židovec Lepej S. The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C. Viruses [Internet]. 2022 July 24 [cited 2024 May 04];14(8). doi: 10.3390/v14081613

L. Radmanić, K. Bodulić, P. Šimičić, A. Vince and S. Židovec Lepej, "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C", Viruses, vol. 14, no. 8, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:625533. [Accessed: 04 May 2024]

Metadata
Title (english)The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C
AuthorLeona Radmanić
AuthorKristian Bodulić
AuthorPetra Šimičić
AuthorAdriana Vince
AuthorSnježana Židovec Lepej
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
In this study, we evaluated the effect of hepatitis C virus eradication using direct-acting antivirals (DAA) on the serum cytokine and growth factor profiles of chronic hepatitis C patients (CHC). Serum concentrations of 12 cytokines and 13 growth factors were measured in 56 patients with CHC before, during the DAA treatment and after sustained virological response using bead-based flow cytometry. Cytokine and growth factor levels were also measured in 15 healthy individuals. The majority of the selected cytokines and growth factors exhibited similar concentrations before, during and after successful DAA treatment, the exceptions being IL-10, EGF, HGF and VEGF. Significantly lower concentrations of IL-10, IL-13, IL-4, IL-4, IL-9, TNF- α and higher levels of Ang-2, HGF and SCF were observed in patients with CHC before and after DAA treatment compared with healthy individuals. Patients with severe fibrosis stages exhibited higher levels of Ang-2 and lower levels of EGF, PDGF-AA and VEGF. Furthermore, IL-4, IL-5 and SCF were characterized as potential biomarkers of DAA treatment using random forest. Additionally, logistic regression characterized EGF as a potential biomarker of severe CHC. Our results suggest inhibition of pro-inflammatory processes and promotion of liver regeneration in CHC patients during DAA treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleViruses
Numberingvol. 14, no. 8, 1613
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14081613
URN:NBNurn:nbn:hr:105:625533
Publication2022-07-24
Document URLhttps://www.mdpi.com/1999-4915/14/8/1613
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-07 08:06:52