Parkinsons disease (PD) is a progressive neurodegenerative disorder caused by the degeneration of dopaminergic neurons in the substantia nigra. It is the main representative of the movement disorder characterized by impoverishment movements. PD is characterized by a variety of symptoms: muscle stiffness due to increased muscle tone-rigidity, slowness (bradykinesia) and blocking movement, resting tremors, loss of postural reflexes and flexion posture. Diagnosis of PD is typically clinical and is based on criteria that include the presence of bradykinesia and / or rigidity, akinetic tremor, absence of atypical signals. Presence of two of the following three signals is required: a good response to levodopa, levodopa-induced involuntary movements, that is dyskinesia, and asymmetrical beginning of disease. Treatment of PD is symptomatic. It is focused on the control of motor symptoms and on the improvement of the quality of life. In the treatment of PD dopaminomimetics (levodopa, dopaminergic receptor agonists), inhibitors of the degradation enzyme dopamine-inhibitors of the enzyme monoamino oxidasa type B (MAO-B), inhibitors of the enzyme catechol-o-methyltransferase (COMT), antiglutamatergics and extremely rarely anticholinergics are being used. Levodopa is the golden standard. Besides pharmacological, there is also neurosurgical treatment of PD. It is indicated in patients who respond to levodopa, but no longer tolerate it because of the side effects such as motoric fluctuations or dyskinesias, or in which the treatment with tolerable doses of levodopa became ineffective. Irreversible methods are applied: palitodomy and thalamotomy. The discovery of stimulation of the basal ganglia by implantation of electrodes (deep brain stimulation - DBS) represents a revolution of neurosurgical treatment of developed forms of PD. Unlike palidotomy and thalamotomy, application of DBS is reversible. Although it has significantly positive effect, this form of treatment unfortunately does not preclude further development of PD.