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doctoral thesis
Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:414053
Angebrandt Belošević, Petra
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Angebrandt Belošević, P. (2023). Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:414053

Angebrandt Belošević, Petra. "Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:414053

Angebrandt Belošević, Petra. "Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:414053

Angebrandt Belošević, P. (2023). 'Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom', Doctoral thesis, University of Zagreb, School of Medicine, accessed 08 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:414053

Angebrandt Belošević P. Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 November 08] Available at: https://urn.nsk.hr/urn:nbn:hr:105:414053

P. Angebrandt Belošević, "Povezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:414053

Metadata
TitlePovezanost genskoga polimorfizma - 455G/A beta-fibrinogena i pojavnosti tromba u aurikuli lijevog atrija u bolesnika s atrijskom fibrilacijom
Title (english)The association of beta-fibrinogen – 455G/A gene polymorphism with left atrial thrombus in patient with atrial fibrillation
AuthorPetra Angebrandt Belošević
MentorAnton Šmalcelj (mentor)
Committee memberDiana Delić-Brkljačić (predsjednik povjerenstva)
Committee memberRajko Kušec (član povjerenstva)
Committee memberBoris Starčević (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-01-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Uvod: Do sada su poznati brojni prediktori tromboze aurikule lijevog atrija, no u tom je području još uvijek mnogo nepoznanica, pogotovo kada je riječ o genetskim prediktorima. Cilj ovoga istraživanja bio je pronaći genski marker koji može biti prediktor tromboze i time poboljšati procjenu tromboembolijskog rizika. Metode i ispitanici: Dizajnirana je opservacijska, unicentrična, retrospektivna studija koja je uključila ukupno 181 bolesnika s atrijskom fibrilacijom. Primarni ishod istraživanja bio je detekcija tromba u aurikuli lijevoga atrija, a svim bolesnicima rađena je genska analiza na - 455 G/A polimorfizam gena za β lanac fibrinogena. Rezultati: Nakon provedene metode uparivanja prema vjerojatnosti sklonosti dviju skupina bolesnika, niti jedna ispitivana varijabla, uključujući polimorfizam - 455 G/A beta-fibrinogena, nije se pokazala neovisnim prediktorom tromboze aurikule lijevog atrija. Rasprava: Rezultati istraživanja u skladu su s do sada objavljenim studijama, gdje još uvijek postoji nesklad u rezultatima te su neka istraživanja pronašla povezanost - 455 G/A polimorfizma s trombogenezom, dok pak neka druga istraživanja nisu pronašla funkcionalnu vezu. Zaključak: Rezultati upućuju na to da tromboza aurikule lijevoga atrija nije neovisno povezana sa - 455 G/A polimorfizmom za β lanac fibrinogena te je vjerojatno posljedica interakcije između gena, te gena i okoliša. No za dokazivanje navedenoga bit će nužna daljnja istraživanja.
Abstract (english)
Introduction: There are many predictors of left atrial appendage thrombosis, but still there are many unknown facts, articularly in the area of genetic predictors. Purpose of this study was to find genetic predictor of thrombosis and to enhance evaluation of thromboembolic risk. Methods: We conducted an observational, retrospective, unicentric study involving 181 patients with AF. Primary outcome of this study was to detect thrombus in left atrial appendage and all patients were scheduled for genetic analysis for - 55G/A β fibrinogen polymorphism. Results: After performing propensity score matching method, none of tested parameters, including - 455G/A polymorphism, were not independent predictors of left atrial appendage thrombosis. Discussion: This results are consistent with the results from many other studies in this field, where some studies have found functional relationship between thrombosis and - 455G/A polymorphism, but still many other studies have not found the same interaction. Conclusion: Results showed that left atrial appendage thrombosis is not independently related with - 455G/A polymorphism for β chain of fibrinogen. It’s probably consequence of interactions between genes, and genes and environment. However, to confirm such statement we need to conduct more research in the future.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:414053
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent74 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-03-20 08:29:20