Acne mechanica is a specific type of acne that occurs as a result of exposing the skin to mechanical factors, such as pressure, friction, or rubbing. In addition to mechanical factors, heat, moisture, occlusion, and dysbiosis also play an important role in the etiopathogenesis of this type of acne. Most commonly, acne mechanica represents an exacerbation of a mild or moderately severe form of acne vulgaris. However, acne mechanica is often associated with various professions such as American football players, dancers, musicians, and medical professionals. The outbreak of the COVID-19 disease pandemic led to an increase in the number of people who have developed a special subtype of acne mechanica caused by the long-term wearing of a protective face mask, which is called maskne. Acne mechanica is clinically presented by the appearance of papules, pustules, and nodules at the sites of action of mechanical factors, while comedones are almost never found. Also, this disorder is characterized by an unusual distribution of lesions. Accordingly, acne mechanica has been described not only on the face, shoulders, back, and chest but also on the neck, arms, and gluteal regions. The diagnosis of acne mechanica is based on anamnesis and clinical features. The first line of treatment is the removal of stimuli, which often leads to spontaneous regression of the disease. If there is no withdrawal of lesions, treatment with topical therapy such as combinations of benzoyl peroxide and adapalene or benzoyl peroxide and clindamycin is required. In the moderate form of acne mechanica or in case of ineffectiveness of the local therapy, in addition to topical treatment, systemic antibiotics are used. Tetracyclines, such as doxycycline and lymecycline, are the most used antibiotics.