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Scientific paper - Review paper
Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease
Diagnostics, 12 (2022), 12; 3172. https://doi.org/10.3390/diagnostics12123172
Tomić Mahečić, Tina; Baronica, Robert; Mrzljak, Anna; Boban, Ana; Hanžek, Ivona; Karmelić, Dora; Babić, Anđela; Mihaljević, Slobodan; Meier, Jens

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Tomić Mahečić, T., Baronica, R., Mrzljak, A., Boban, A., Hanžek, I., Karmelić, D. ... Meier, J. (2022). Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease. Diagnostics, 12. (12). doi: 10.3390/diagnostics12123172

Tomić Mahečić, Tina, et al. "Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease." Diagnostics, vol. 12, no. 12, 2022. https://doi.org/10.3390/diagnostics12123172

Tomić Mahečić, Tina, Robert Baronica, Anna Mrzljak, Ana Boban, Ivona Hanžek, Dora Karmelić, Anđela Babić, Slobodan Mihaljević and Jens Meier. "Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease." Diagnostics 12, no. 12 (2022). https://doi.org/10.3390/diagnostics12123172

Tomić Mahečić, T., et al. (2022) 'Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease', Diagnostics, 12(12). doi: 10.3390/diagnostics12123172

Tomić Mahečić T, Baronica R, Mrzljak A, Boban A, Hanžek I, Karmelić D, and sur.. Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease. Diagnostics [Internet]. 2022 December 15 [cited 2024 May 02];12(12). doi: 10.3390/diagnostics12123172

T. Tomić Mahečić, et al., "Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease", Diagnostics, vol. 12, no. 12, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:169414. [Accessed: 02 May 2024]

Metadata
Title (english)Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease
AuthorTina Tomić Mahečić
AuthorRobert Baronica
AuthorAnna Mrzljak
AuthorAna Boban
AuthorIvona Hanžek
AuthorDora Karmelić
AuthorAnđela Babić
AuthorSlobodan Mihaljević
AuthorJens Meier
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Over the last decades, individualized approaches and a better understanding of coagulopathy complexity in end-stage liver disease (ESLD) patients has evolved. The risk of both thrombosis and bleeding during minimally invasive interventions or surgery is associated with a worse outcome in this patient population. Despite deranged quantitative and qualitative coagulation laboratory parameters, prophylactic coagulation management is unnecessary for patients who do not bleed. Transfusion of red blood cells (RBCs) and blood products carries independent risks for morbidity and mortality, including modulation of the immune system with increased risk for nosocomial infections. Optimal coagulation management in these complex patients should be based on the analysis of standard coagulation tests (SCTs) and viscoelastic tests (VETs). VETs represent an individualized approach to patients and can provide information about coagulation dynamics in a concise period of time. This narrative review will deliver the pathophysiology of deranged hemostasis in ESLD, explore the difficulties of evaluating the coagulopathies in liver disease patients, and examine the use of VET assays and management of coagulopathy using coagulation factors. Methods: A selective literature search with PubMed as the central database was performed with the following.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 12, 3172
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12123172
URN:NBNurn:nbn:hr:105:169414
Publication2022-12-15
Document URLhttps://www.mdpi.com/2075-4418/12/12/3172
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-25 11:15:12