prikaz prve stranice dokumenta Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
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Scientific paper - Original scientific paper
Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
Biomedicines, 10 (2022), 12; 3178. https://doi.org/10.3390/biomedicines10123178
Ivković, Irena; Limani, Zgjim; Jakovčević, Antonia; Huić, Dražen; Prgomet, Drago

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Ivković, I., Limani, Z., Jakovčević, A., Huić, D. & Prgomet, D. (2022). Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123178

Ivković, Irena, et al. "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer." Biomedicines, vol. 10, no. 12, 2022. https://doi.org/10.3390/biomedicines10123178

Ivković, Irena, Zgjim Limani, Antonia Jakovčević, Dražen Huić and Drago Prgomet. "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer." Biomedicines 10, no. 12 (2022). https://doi.org/10.3390/biomedicines10123178

Ivković, I., et al. (2022) 'Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer', Biomedicines, 10(12). doi: 10.3390/biomedicines10123178

Ivković I, Limani Z, Jakovčević A, Huić D, Prgomet D. Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer. Biomedicines [Internet]. 2022 December 08 [cited 2025 January 12];10(12). doi: 10.3390/biomedicines10123178

I. Ivković, Z. Limani, A. Jakovčević, D. Huić and D. Prgomet, "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer", Biomedicines, vol. 10, no. 12, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:993098. [Accessed: 12 January 2025]

Metadata
Title (english)Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
AuthorIrena Ivković
AuthorZgjim Limani
AuthorAntonia Jakovčević
AuthorDražen Huić
AuthorDrago Prgomet
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Nuclear Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Othorhinolaryngology and Head and Neck Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (english)
Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC. The aim of our study was to determine expression levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 in tissue specimens of invasive and non-invasive PTC. Our hypothesis was that expression levels of these biomarkers correlate with the development of locally invasive PTC. In our single-center study we retrospectively investigated MMP and TIMP expression levels in 50 samples of thyroid tissue diagnosed as locally invasive papillary carcinoma (study group) and 30 samples of thyroid tissue diagnosed as non-invasive, non-metastatic papillary carcinoma (control group). Tissue specimens were immunohistochemically stained with primary monoclonal antibodies against MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2. When correlating expression levels of MMPs and TIMPs in thyroid tissue, statistically significant differences were found for MMP-1 and TIMP-1 expression (p < 0.001; Mann–Whitney U test) with the highest levels of expression in the invasive PTC group. Although expression of MMP-9 and TIMP-2 was higher in invasive PTC, the differences were not statistically significant. Elevated expression of MMP-1 and TIMP-1 in tumor tissue can predict invasiveness for PTC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 12, 3178
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123178
URN:NBNurn:nbn:hr:105:993098
Publication2022-12-08
Document URLhttps://www.mdpi.com/2227-9059/10/12/3178
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-27 08:30:11