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doctoral thesis
Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom
Zagreb: University of Zagreb, School of Medicine, 2011. urn:nbn:hr:105:856131
Marković-Pleše, Silva
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Marković Pleše, S. (2011). Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:856131

Marković Pleše, Silva. "Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:856131

Marković Pleše, Silva. "Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:856131

Marković Pleše, S. (2011). 'Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:856131

Marković Pleše S. Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2011 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:856131

S. Marković Pleše, "Mehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:105:856131

Metadata
TitleMehanizmi djelovanja interferona beta u liječenju pacijenata s multiplom sklerozom
Title (english)Immunomodulatory mechanisms of interferon beta in patients with multiple sclerosis
AuthorSilva Marković-Pleše
VIAF: 305480296
Mentor Vesna Brinar (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2011-07-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
IFNβ je korišten tijekom proteklog desetljeća kao učinkovita prva linija terapije protiv RR MS, no njegovi mehanizmi djelovanja još nisu u potpunosti razjašnjeni. Naša in-vitro studija je karakterizirala imunoregulatorne efekte IFNβ-a na proizvodnju Th17 regulatornih citokina od strane dendritičkih stanica i B-limfocita. IFNβ inhibira IL-1β, IL-23 i TGF-β koji potiču Th17 staničnu diferencijaciju, te inducira IL-27, IL-12p35 i IL-10, koje se suprimiraju. Naši rezultati impliciraju da administracija visokih doza rekombinantnog IFNβ, koji ima dokazani terapeutski učinak, može pojačati prirodnu IFNβ-posredovanu kontrolu autoimunog odgovora. Navedeni rezultati su identificirali biomarkere Th17 stanične aktivnosti koji su povezani s kliničkom aktivnošću bolesti, te mogu poslužiti kao mjera učinkovitosti terapije IFNβ-om.
Abstract (english)
IFNβ has been used over the past decade as an effective first-line therapy for RR MS, but its mechanisms of action are not yet fully understood. Our in-vitro study has characterizef the immunoregulatory effects of IFNβ on the production of Th17 regulatory cytokines by dendritic cells and by B-lymphocytes. Our results have demonstrated that IFNβ inhibits secretion of IL-1β, IL-23 and TGF-β, which promote Th17 cell differentiation, and induces IL-27, IL-12p35 and IL-10, which suppress it. Our results imply that the administration of high doses of recombinant IFNβ, which has a proven therapeutic effect, can increase the natural IFNβ-mediated control of autoimmune responses. Our results have identified biomarkers of Th17 cell activity that correlate with clinical disease activity and may serve as a measure of the effectiveness of IFNβ therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:856131
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent73 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 06:37:52