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doctoral thesis
Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa
Zagreb: University of Zagreb, School of Medicine, 2011. urn:nbn:hr:105:185352
Dobrić, Ivan
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Dobrić, I. (2011). Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:185352

Dobrić, Ivan. "Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:185352

Dobrić, Ivan. "Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:185352

Dobrić, I. (2011). 'Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 02 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:185352

Dobrić I. Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2011 [cited 2024 December 02] Available at: https://urn.nsk.hr/urn:nbn:hr:105:185352

I. Dobrić, "Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:105:185352

Metadata
TitleUčinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa
Title (english)The effect of pentadecapeptide BPC 157 on reflux esophagitis during acute pancreatitis
AuthorIvan Dobrić
MBZ: 10082
Mentor Mate Majerović (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2011-07-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj istraživanja bio je pojava i progresija duodenogastroezofagealnog refluksa te njegova pogoršanja uslijed induciranog pankreatitisa te istraživanje potencijelnih terapijskih mogućnosti pentadekapeptida BPC 157. Do sada su u više navrata opisane sistemske komplikacije akutnog pankreatitisa. Osim opisanih, akutni pankreatitis dovodi i do komplikacija vezanih uz integritet i motilitet probavnog trakta, od kojih su do sada najčešće opisane one vezane za želudac i duodenum, dok su komplikacije na jednjaku vrlo slabo poznate. Istraživanje je provedeno na ženkama Wistar Albino štakora. Duodenogastroezofagealni refluks induciran je implantacijom cjevčice u pilorički sfinkter, dok je akutni pankreatitis induciran podvezivanjem glavnoga žučnog voda ispred otvaranja u duodenum. Istraženi su i opisani učinci pentadekapeptida BPC 157 na makroskopske i histološke promjene sluznice jednjaka te na tlak donjega ezofagealnog sfinktera, kao i na makroskopske, histološke i biokemijske promjene uslijed akutnog pankreatitisa. Rezultati su evaluirani nakon 24 sata. Bez obzira na akutni pankreatitis, pentadekapeptid BPC 157 održava tonus DES, sprečava nastanak makroskopski vidljivih promjena jednjaka i oštećenja integriteta rožnatog sloja sluznice jednjaka. Bez obzira na to što je kod svih životinja došlo do pojave akutnog pankreatitisa, u tretiranih je životinja verificirana niža serumska koncentracija lipaza, a opažen je i povoljan učinak u sprečavanju nastanka edema i nekroze pankreasa.
Abstract (english)
The development of of duodenogastroesophageal reflux, it's worsening related to acute pancreatitis, and potential therapeutic effect of pentadecapeptie BPC 157 were the main goals of this research. Systemic complications of acute pancreatitis were described in numerous articles. The acute pancreatitis also badly influences digestive integrity and motility. This effects are mostly known to be developed in stomach and duodenum, while esophagus complications are poorly described and understood. The female Wistar albino rats were used in this research. Duodenogastroesophageal reflux was induced by implanting the plastic tube through pylorus, amd acute pancreatitis by ligating main bile duct just proximally to it's entering into duodenum. The results were evaluated after 24 hours. The effect of pentadecapeptide BPC 157 is described through the results describing macroscopical and hystological changes, the lowers esophageal sphyncter pressure, as well as macroscopic, hystologic and biochemical changes caused by acute pancreatitis. Despite the acute pancreatitis developed, pentadecapeptide BPC 157 keeps the lower esophageal sphyncter strenght, prevents macroscopically identified esophageal changes, and protects corneal layer integrity. Although all the animals developed acute pancreatitis, the lipase serum level concentration was lower in treated animals, as well as edema and necrosis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:185352
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent122 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 06:38:35