INTRODUCTION: Clinical studies about the influence of clinical parameters of epilepsy and characteristics of patients on the result of qualitative/semiquantitative interictal SPECT analysis have been shown inconsistent results. Furthermore, the use of SPECT method in paediatric population has been evaluated in smaller number of studies and in smaller number of cases than adults. AIM: The aim of this study was to investigate clinical importance of interictal 99mTc-HMPAO SPECT method in evaluation of functional brain damage in children with partial epilepsy and the influence of certain patients' characteristics and clinical parameters of epilepsy. RESULTS: Boys with symptomatic epilepsy have statistically higher number of bilateral and left-sided changes on 99mTc-HMPAO SPECT, regardless the refractory nature of symptomatic epilepsy, while girls have more normal 99mTc-HMPAO SPECT findings. Average number of ROI with regional hypoperfusion in children with idiopathic partial epilepsies gradually increases in accordance to decline in pychological testing and that number is highest in children with border IQ/SMR and with positive Bender test, regardless the refractory nature of epilepsy. In children with well controlled epilepsy and positive Bender test there is significantly higher number of altered SPECT findings and left ROI with hypoperfusion, while children with well controlled symptomatic epilepsy and Bender have statistically higher number of ROI with hypoperfusion. There is statistical significance of correlation between the number of ROI with regional hypoperfusion and the age at time of first seizure and duration of epilepsy, not considering the refractory nature and aetiology of partial epilepsy. The age at the time of first seizure, epilepsy duration and/or the age at the time of 99mTc-HMPAO SPECT have predictive value for number of ROI with regional hypoperfusion on 99mTc-HMPAO SPECT, especially in the group of refractory idiopathic epilepsy. In children with secondary generalisation of seizures, the most frequent ROI with regional hypoperfusion are in temporal region and in children without secondary generalization of seizures the most frequent ROI are in frontal regions. The finding of 141 99mTc-HMPAO SPECT changes in children with symptomatic epilepsy is not always in accordance with anatomical changes on brain MRI; it depends on refractory nature of epilepsy and it is reflection of functional brain damage. Visual and semiquantitative 99mTc-HMPAO SPECT analysis reveals statistically higher number of normal findings than EEG findings and these changes are more frequently situated on only one brain hemisphere. Number of regions with regional hypoperfusion is statistically higher in children treated with polytherapy, regardless the aetiology of epilepsy. CONCLUSION: Interictal 99mTc-HMPAO SPECT method has clinical significance in evaluation of functional brain damage in children with partial epilepsy. Characteristics of patients (age, sex, results of psychological testing, previous febriles seizures) and clinical parameters of disease (age ast the the of diagnosis, duration of epilepsiy, intractability, number of antiepileptics in therapy) can influence the intensity and localization of regional brain hypoperfusion regardless the aetiology and catastrophic nature of partial epilepsy.