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doctoral thesis
Koštani status u djece oboljele od kronične upalne bolesti crijeva
Zagreb: University of Zagreb, School of Medicine, 2010. urn:nbn:hr:105:273388
Senečić-Čala, Irena
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Senečić Čala, I. (2010). Koštani status u djece oboljele od kronične upalne bolesti crijeva (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:273388

Senečić Čala, Irena. "Koštani status u djece oboljele od kronične upalne bolesti crijeva ." Doctoral thesis, University of Zagreb, School of Medicine, 2010. https://urn.nsk.hr/urn:nbn:hr:105:273388

Senečić Čala, Irena. "Koštani status u djece oboljele od kronične upalne bolesti crijeva ." Doctoral thesis, University of Zagreb, School of Medicine, 2010. https://urn.nsk.hr/urn:nbn:hr:105:273388

Senečić Čala, I. (2010). 'Koštani status u djece oboljele od kronične upalne bolesti crijeva ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:273388

Senečić Čala I. Koštani status u djece oboljele od kronične upalne bolesti crijeva [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2010 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:273388

I. Senečić Čala, "Koštani status u djece oboljele od kronične upalne bolesti crijeva ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2010. Available at: https://urn.nsk.hr/urn:nbn:hr:105:273388

Metadata
TitleKoštani status u djece oboljele od kronične upalne bolesti crijeva
Title (english)Bone status in children with inflammatory bowel disease
AuthorIrena Senečić-Čala
MBZ: 178601
Mentor Sanja Kolaček (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2010-06-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
U djece s kroničnom upalnom bolešću crijeva može se javiti poremećaj koštanog metabolizma koji se očituje smanjenom mineralnom gustoćom kosti i povećanim rizikom nastanka osteoporoze u odrasloj dobi. Uzroci nastanka koštanog poremećaja kao niti njegova učestalost nisu u cijelosti ispitani. Primarni cilj ovog rada bio je ispitivanje koštanog metabolizma i njegovog poremećaja na način da se utvrdi učestalost poremećaja mineralizacije kosti i ispita utjecaj različitih čimbenika na koštani status. Stoga smo pratili koštani metabolizam pomoću DXA, ultrazvuka petne kosti i biokemijskih parametara koštanog preoblikovanja u 58 djece s kroničnom upalnom bolešću crijeva, u tri mjerenja tijekom perioda od godinu dana. Rezultati istraživanja su pokazali da je u naših ispitanika smanjena koštana masa prisutna u 10% na početku, i u 8,7% ispitanika na kraju studije. Nije bilo razlika između skupina djece prema dijagnozi i prema spolu. Utjecaj stanja uhranjenosti i rasta na mineralnu gustoću kosti pokazao se pozitivan i značajan. Nepovoljan utjecaj hipovitaminoze D na mineralizaciju kosti nije dokazan uz napomenu da je većina ispitanika bila na supstituciji kalcija i vitamina D. Nije nađena povezanost mineralne gustoće kosti pomoću DXA i stupnja spolnog razvoja. Nije dokazan pozitivan učinak enteralne prehrane na mineralnu gustoću kosti. Dulje trajanje bolesti kao niti liječenje steroidima nisu u ovom ispitivanju bili značajni čimbenici za nastanak poremećaja mineralizacije kosti. Međutim, jasna je negativna povezanost aktivnosti bolesti s biokemijskim i ultrazvučnim denzitometrijskim parametrima. Ovo istraživanje je također pokazalo, da se u djece s kroničnom upalnom bolešću crijeva tijekom praćenja, s boljom kontrolom osnovne bolesti, poboljšao nutritivni status bolesnika i održao primjeren rast i spolni razvoj. Sukladno tomu, dinamika se koštanog metabolizma mijenjala prema izgradnji, rastu i poboljšanoj mineralizaciji kosti.
Abstract (english)
In children with inflammatory bowel disease impairment of bone metabolism may occur with increased risk of osteoporosis in adulthood. The incidence and causes of bone disorder are not well evaluated. The aim of this study was to evaluate bone metabolism and its impairment by determining the incidence of bone mineralization disorder and to indentify the influence of different clinical factors on bone status. Therefore, bone metabolism was assessed by DXA, calcaneal ultrasound and biochemical parameters of bone turnover in 58 children with inflammatory bowel disease. Three times measurements during one year were performed. Decreased bone mineral density was found in 10% od patients at the begining , and in 8,7% of patients at the end of the study. There were no difference in groups according to diagnosis and gender. The positive influence of nutritional status and growth on bone mineral density was significant. The negative influence of vitamin D deficiency was not confirmed, but the majority of patients received vitamin D and calcium supplements. There was no correlation between pubertal development and bone mineral density obtained by DXA. The positive effect of enteral nutrition on bone mineralization was not confirmed. The duration of disease and steroid treatment were not identified as risk factors for bone mineral disorder in this study. However, significant negative correlation of disease activity with biochemical and ultrasound parameters was found. This study also showed that during one year of follow up, with better control of the disease, growth and pubertal development were maintained and nutritional status improved in our patients. Accordingly, the dynamics od bone metabolism changed towards bone modeling, growth and increased bone mineralization.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:273388
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent165 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 06:54:49