prikaz prve stranice dokumenta Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom
  Download
PDF 825.5 KB
doctoral thesis
Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom
Zagreb: University of Zagreb, School of Medicine, 2012. urn:nbn:hr:105:625928
Lovrić, Eva
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Lovrić, E. (2012). Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:625928

Lovrić, Eva. "Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom ." Doctoral thesis, University of Zagreb, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:105:625928

Lovrić, Eva. "Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom ." Doctoral thesis, University of Zagreb, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:105:625928

Lovrić, E. (2012). 'Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:625928

Lovrić E. Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2012 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:105:625928

E. Lovrić, "Izraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:105:625928

Metadata
TitleIzraženost glipikana-3, beta-katenina i CD34 u hepatocelularnom karcinomu bolesnika s transplantiranom jetrom
Title (english)Expression of glypican-3, beta-catenin and CD34 in hepatocellular carcinoma in patients with orthotopic liver transplantation
AuthorEva Lovrić
Mentor Ana Borovečki (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2012-12-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj istraživanja je bio odrediti morfološke karakteristike hepatocelularnog karcinoma (HCK-a), kliničke i laboratorijske pokazatelje i imunohistokemijske karakteristike izraženosti glipikana-3 (GPC3), beta-katenina i CD34 u HCK-u, njihovu međusobnu povezanost te utjecaj na ishod bolesnika unutar i izvan milanskih kriterija. 71 bolesnik sa primarnim HCK-om, liječen je transplantacijom jetre. Analizirane su morfološke karakteristike tumora - broj i veličina, arhitekturalni tip rasta, histološki tip, stupanj diferencijacije, prisutnost makro i mikrožilne invazije. 30 bolesnika je bilo unutar milanskih kriterija i 41 bolesnik izvan milanskih kriterija. Kod 14 bolesnika je bila prisutna žilna invazija tumora. Pozitivna izraženost GPC3 je bila prisutna u 67.60% slučajeva HCK-a, citoplazmatske lokalizacije. Pozitivna izraženost beta-katenina bila je prisutna u svim HCK-a, membranske lokalizacije. Izraženost CD34 u svim slučajevima bila je jakog intenziteta. Karakteristike izraženosti biljega GPC3, beta-katenina i CD34 ne razlikuju se u skupinama bolesnika određenih milanskim kriterijima. Analizirane skupine bolesnika određene milanskim kriterijima nisu se razlikovale ukupnim preživljenjem, niti vremenom do ponovne pojave bolesti. Žilna invazija bila je značajno češće prisutna u skupini bolesnika s kraćim vremenom do ponovne pojave bolesti. Jaki intenzitet izraženosti beta-katenina bio je značajno češće prisutan u skupini bolesnika dužeg ukupnog preživljenja.
Abstract (english)
The aim of the study was to determine morphological features of HCC, clinical and laboratory data and characteristics of immunohistochemical expression of glipican-3 (GPC3), beta - catenin and CD34 in HCC, their mutual association and prognostic value, with special regard to those patient groups meeting and those exceeding milan criteria. 71 patients with primary HCC have undergone liver transplantation. Pathological tumor characteristics - number and size of tumors, architectural pattern, histological type, differentiation grade, and macro and microvascular invasion were analyzed. 30 patients meeting and 41 exceeding milan criteria. Vascular invasion was present in 14 patients. Cytoplasmatic GPC3 positivity was observed in 67.60% cases of HCC. Membrane beta-catenin was expressed in all cases of HCCs. The strong expression of CD34 was observed in all cases of HCCs. There was no significant difference between group meeting and exceeding milan criteria according to expression's characteristics of GPC3, beta-catenin and CD34. There was no difference in survival rate and recurrence between patient groups meeting and exceeding milan criteria. Vascular invasion was more frequently observed in patients group with shorter period of recurrence. Membranous, strong intensity of beta-catenin was more frequently observed in patients group with longer survival rate.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:625928
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent69 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 07:04:02