prikaz prve stranice dokumenta Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora
  Download
PDF 1.18 MB
doctoral thesis
Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora
Zagreb: University of Zagreb, School of Medicine, 2013. urn:nbn:hr:105:802317
Maraković, Jurica
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Maraković, J. (2013). Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:802317

Maraković, Jurica. "Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora ." Doctoral thesis, University of Zagreb, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:105:802317

Maraković, Jurica. "Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora ." Doctoral thesis, University of Zagreb, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:105:802317

Maraković, J. (2013). 'Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 18 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:802317

Maraković J. Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2013 [cited 2024 May 18] Available at: https://urn.nsk.hr/urn:nbn:hr:105:802317

J. Maraković, "Učinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:105:802317

Metadata
TitleUčinak promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen i tlak cerebrospinalnog likvora
Title (english)Effect of changes in serum and cerebrospinal fluid osmolarity on cerebrospinal fluid volume and pressure
AuthorJurica Maraković
MBZ: 339914
Mentor Darko Orešković (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2013-03-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
U konzervativnom liječenju povišenog intrakranijskog tlaka već dugo se koriste hiperosmolarne otopine (najviše manitol) koje se daju intravenski, ali točan mehanizam njihovog djelovanja na snižavanja intrakranijskog tlaka nije u potpunosti razjašnjen. Stoga je u ovom radu eksperimentalno, na mačkama proučavan utjecaj promjene osmolarnosti krvi i cerebrospinalnog likvora na volumen cerebrospinalnog likvora, te povezanost tih promjena volumena likvora s intrakranijskim tlakom. U tu svrhu korišteni su modeli direktne ventrikulo-akveduktalne i ventrikulo-cisternalne perfuzije s izoosmolarnom i hiperosmolarnom otopinom umjetnog likvora, spontanog istjecanja likvora iz cisterne magne i mjerenja tlaka likvora u lateralnoj moždanoj komori. Promjene osmolarnosti krvi vršene su intravenskim davanjem 20% manitola, te intraperitonealnim davanjem destilirane vode. Dobiveni rezultati pokazali su da promjene osmotskih sila u likvorskom sustavu dovode do promjena ukupnog volumena cerebrospinalnog likvora i da su promjene tlaka likvora (intrakranijskog tlaka) direktno povezane s tim promjenama volumena likvora. Veličina promjene volumena likvora ovisi o površini likvorskog sustava koja je izložena promjenama osmotskih sila. Također je pokazano da pri fiziološkom tlaku likvora, bez promjena osmotskih sila nema „čistog“ stvaranja niti apsorpcije likvora. Svi dobiveni rezultati nisu u skladu s klasičnom hipotezom o sekreciji, cirkulaciji i apsorpciji likvora, ali su u skladu s predloženom novom hipotezom o dinamici cerebrospinalnog likvora.
Abstract (english)
Hyperosmolar solutions (mostly mannitol) have long been used in clinical practice to reduce intracranial pressure, but the exact mechanism by which this effect occurs is still unclear. So, in this study we wanted to investigate experimentally, on cats, the effect of changes in serum and CSF osmolarity on CSF volume and how this changes of CSF volume influence on intracranial pressure. For this purpose we used experimental models of direct ventriculo-aqueductal and ventriculo-cisternal perfusion with both isoosmolar and hyperosmolar aCSF, the free drainage of CSF from a cannula put into the cisterna magna and the measuring of CSF pressure by the cannula put into the lateral ventricle of the brain. Serum osmolarity was changed by intravenous application of 20% mannitol or intraperitoneal administration of distilled water. Obtained result showed that the changes of osmotic forces in CSF compartments leads to changes of total CSF volume and that changes of CSF pressure are directly connected with this changes of CSF volume. The extent of CSF volume changes depends on the size of contact area of CSF system that was exposed to the changes of osmotic forces. It was also shown that with physiological intracranial pressure, without changes of osmotic forces, there was no “net” CSF formation or absorption. All obtained results contradict the classic hypothesis of secretion, circulation and absorption of CSF, but support proposed new hypothesis of CSF hydrodynamics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:802317
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent101 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 07:07:49