Objective: intrauterine growth restriction (IUGR) is considered as a risk factor for neurodevelopmental disorders and unfavorable long-term outcome. Aim of the study: to evaluate predictive validity of Doppler arterial indices and umbilical cord acid-base status for early neurological outcome of the newborns with IUGR and to establish reference values of Doppler parameters in the prediction of adverse neurological outcome. Methods: a prospective study included 60 IUGR neonates born between 37th and 40 th week of gestation. Umbilical artery resistance index (URI), middle cerebral artery resistance index (CRI), and cerebro-umbilical (C/U) ratio were followed during the pregnancy. Umbilical cord samples (arterial and venous) were collected at birth for analysis (pH, pO2, pCO2 ). Neurological outcome was evaluated during the first week of life according to brain ultrasound findings and Amiel-Tison neurological assessment at term (ATNAT). Results: brain ultrasound lesions were found in 32 (53,37%) of the newborns, while 42 (70%) had non-optimal neurological status according to ATNAT. Generally, Doppler indices had higher predictive validity for the early neurological outcome than umbilical cord acid-base status. According to P value of the statistical analysis, the differences between the normal and pathological results were more emphasized in ATNAT than brain ultrasound findings. C/U ratio had the highest predictive validity for early neurological disturbances, with the relative risk for adverse neurological outcome at reference validity of 1,13. Conclusions: Doppler indices are highly predictive in the risk assessment for adverse neurological outcome among IUGR infants. C/U ratio was the best predictor of neurological outcome. However, the non-optimal neurological outcome at everage values of C/U ratios more than 1 confirmed that IUGR is connected with the possibility of neurological seqelae even without fetal hemodinamics compromise. Sensitivity and specificity of the ATNAT showed superiority in detecting early neurological disturbances compared to brain ultrasound, so it has to be the basic method for the neurological evaluation of the IUGR newborns, as well as the method of screening those in need for long-term follow up.