Bone healing process is very complex. Increase in blood flow around the fracture during the healing process increases the temperature. Infrared thermography is a method of measuring body temperature that can detect thermal changes. A prospective study was conducted on 50 patients with the aim of investigating thermal changes during the healing of distal radius fractures and on 30 healthy volunteers for the purpose of method validation. The Flir ThermaCam B2 (Flir System Inc., Oregon, SAD) was used for all measurements. Thermographic recordings were made at one, three, five, 11 and 23 weeks after fracture. In healthy volunteers, thermographic recordings were made before plaster of Paris immobilization and 24 hours later. The contralateral hand was used for comparison. Patients' x-rays were also analyzed and fracture healing was classified by Hammer and RUSS methods. Significant temperature differences between patients with fractures and healthy volunteers at one, three, five and 11 weeks after the fracture were found, while at 23 weeks there was no temperature difference. The highest temperature differences were at the 3rd week after fracture and then the temperature difference gradually decreased. The dynamics analysis of thermal changes clearly demonstrated the influence of time on temperature changes between broken and healthy hands. Patients with repositioned fractures had a significant difference in temperature relative to those without repositioning and also a lower chance that fracture will heal in five weeks. Patients with a lower temperature difference and a lower drop in temperature had a greater chance of healing. Infrared thermography is a method that is not harmful or invasive and can be used as an additional method of fracture healing follow up in combination with x-ray and clinical examination.