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master's thesis
Guillain Barre sindrom
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:177838
Rajić, Ivana
University of Zagreb
School of Medicine
Department of Neurology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Rajić, I. (2015). Guillain Barre sindrom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:177838

Rajić, Ivana. "Guillain Barre sindrom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:177838

Rajić, Ivana. "Guillain Barre sindrom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:177838

Rajić, I. (2015). 'Guillain Barre sindrom', Master's thesis, University of Zagreb, School of Medicine, accessed 05 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:177838

Rajić I. Guillain Barre sindrom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 November 05] Available at: https://urn.nsk.hr/urn:nbn:hr:105:177838

I. Rajić, "Guillain Barre sindrom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:177838

Metadata
TitleGuillain Barre sindrom
Title (english)Guillain Barre syndrome
AuthorIvana Rajić
MentorMarija Žagar (mentor)
Committee memberErvina Bilić (predsjednik povjerenstva)
Committee memberMario Habek (član povjerenstva)
Committee memberMarija Žagar (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Neurology)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Guillian Barre sindrom (GBS) je akutna upalna autoimuna neuropatija koja se očituje progresivnom, simetričnom mišićnom slabošću udruženom s oslabljenim ili potpuno odsutnim dubokim tetivnim refleksima. Intenzitet kliničke slike može biti od blagog pa do vrlo teškog oblika, s kompletnom oduzetošću ruku, nogu, trupa, mišića lica, bulbarno inerviranih mišića kao i respiratornih mišića. Uz sliku blage simetrične mišićne slabosti, nažalost GBS se može manifestirati kompletnom paralizom svih udova, facijalnih, bulbarnih i respiratornih mišića. ----- Važnu ulogu u nastanku GBS ima prethodna infekcija koja može dovesti do pokretanja autoimune reakcije koja dovodi do upalnog oštećenja mijelina i/ili aksona živca, a kao najčešća infekcija spominje se ona s Campilobakter jejuni. ----- Najčešći oblik GBS u Europi je akutna upalna demijelinizacijska neuropatija (ADIP), a rijetki oblici su akutna motorna aksonalna neuropatija (AMAN), akutna motorna i osjetna neuropatija (AMSAN) i Miller Fischerov sindrom (MFS). ----- Dijagnoza GBS se temelji na kliničkoj slici, analizi cerebrospinalnog likvora u kojem dominiraju povišeni proteini uz uredan nalaz stanica (albuminocitološka disocijacija) i EMNG nalazu. Primjenom plazmafereze i imunoglobulina postignuti su pomaci u liječenju i ishodu bolesti.
Abstract (english)
Guillain Barre syndrome (GBS) is an acute inflammatory immunomodulating neuropathy, manifested by progressive symmetrical muscle weakness associated with weak or completely absent deep tendon reflexes. Except this mild symmetrical muscle weakness, unfortunately GBS may manifest with complete paralysis of all limbs, facial, bulbar and respiratory muscles. ----- A key role in the development of GBS have preceding infections that leads to inflammatory damage of myelin and /or nerve axons, and the most common infection is Campylobacter jejuni. ----- The most common form of GBS is acute inflammatory demyelinating neuropathy (ADIP) and the more common forms are acute motor axonal neuropathy (AMAN), acute motor and sensory neuropathy (AMSAN) and Miller Fischer syndrome (MFS). ----- According to clinical picture, analysis of cerebrospinal fluid (dominated by an elevated protein with normal findings of leukocytes) and EMG findings (slowing of conduction velocity) is based the diagnosis of GBS. ----- Plasmapheresis and immunoglobulin have made improving in the clinical picture, reducing the number of relapses and mortality.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:177838
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-04-11 09:04:09