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doctoral thesis
Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:719270
Ostojić, Ana
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Ostojić, A. (2019). Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:719270

Ostojić, Ana. "Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka ." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:719270

Ostojić, Ana. "Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka ." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:719270

Ostojić, A. (2019). 'Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:719270

Ostojić A. Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:105:719270

A. Ostojić, "Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:719270

Metadata
TitlePovezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka
Title (english)Association between CXCL9 and CXCL10 chemokine gene polymorphisms and acute graft rejection after liver transplantation
AuthorAna Ostojić
MentorAnna Mrzljak (mentor)
MentorTomislav Kelava (komentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2019-11-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Akutno stanično odbacivanje (ASO) klinički je vrlo značajan događaj koji ugrožava preživljenje i presatka i primatelja jetre. Kemokini CXCL9/10 imaju ključnu ulogu u regrutiranju T-limfocita u presadak te su njihove povišene serumske vrijednosti povezane s pojavom ASO-a. Međutim, moguća povezanost između jednonukleotidnog polimorfizma gena (PG) za kemokine CXCL9/10 i ASO-a nakon transplantacije jetre nije do sada istražena. PG za CXCL9 (rs10336) i CXCL10 (rs3921 i rs8878) određen je polimeraza lančanom reakcijom kod 215 bolesnika koji su transplantirani zbog alkoholne bolesti jetre s hepatocelularnim karcinomom ili bez njega. Dijagnoza ASO-a histološki je utvrđena kod 27,4% bolesnika. Dokazana je povezanost između ASO-a i mlađe životne dobi davatelja te bodovnog sustava MELD. Međutim, istraživanje je utvrdilo da PG za kemokine CXCL9 (rs10336) i CXCL10 (rs3921 i rs8878) nije povezan ni s pojavnosti ASO-a ni sa stupnjem težine ASO-a nakon transplantacije jetre. Ipak, bolesnici s genotipom CXCL9 (rs10336) AA razvili su ASO značajno ranije, što upućuje na sudjelovanje CXCL9 u razvoju ASO-a.
Abstract (english)
Acute cellular rejection (ACR) is a clinically important event that negatively affects the survival of the graft and the recipient. As potent T cell- chemoattractants, CXCL9 and CXCL10, have been demonstrated to play a central role in the immune response against transplant tissue, leading to ACR. While increased serum concentrations of CXCL9/10 are associated with ACR occurrence, the association between CXCL9/10 single nucleotide polymorphisms (SNPs) and ACR after liver transplantation (LT) remains unknown. SNPs of CXCL9 (rs10336) and CXCL10 (rs3921) were determined by polymerase chain reaction in 215 recipients transplanted due to alcoholic cirrhosis with or without hepatocellular carcinoma. 27.4% recipients were diagnosed with ACR that was defined as biopsy-proven within 6 months after LT. Recipients that developed ACR had significantly higher MELD scores pre-LT and received significantly younger liver grafts. There was no association between CXCL9/10 genotypes and overall incidence of ACR, the severity of ACR and the number of rejection episodes. However, patients with CXCL9 genotype AA developed ACR earlier, suggesting the involvement of CXCL9-mediated processes in ACR development.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:719270
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent75 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 08:45:05