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master's thesis
Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:849419
Kusulja, Marija
University of Zagreb
School of Medicine
Department of Infectious Diseases

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kusulja, M. (2015). Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:849419

Kusulja, Marija. "Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:849419

Kusulja, Marija. "Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:849419

Kusulja, M. (2015). 'Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom', Master's thesis, University of Zagreb, School of Medicine, accessed 05 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:849419

Kusulja M. Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 November 05] Available at: https://urn.nsk.hr/urn:nbn:hr:105:849419

M. Kusulja, "Uloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:849419

Metadata
TitleUloga dekompresijske kranijektomije u liječenju malignog edema mozga u bolesnika s herpes simpleks virusnim encefalitisom
Title (english)The role of decompressive craniectomy in treating malignant cerebral oedema in patients with herpes simplex encephalitis
AuthorMarija Kusulja
MentorMarija Santini (mentor)
Committee memberBruno Baršić (predsjednik povjerenstva)
Committee memberGoran Tešović (član povjerenstva)
Committee memberMarija Santini (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Herpes simpleks virus uzročnik je 10-20% svih encefalitisa. Uvođenjem aciklovira u liječenje ove bolesti smanjena je smrtnost, no ona i dalje ostaje značajna, uglavnom zbog razvoja edema i hernijacije mozga. ----- Dekompresijska kranijektomija opisana je kao metoda liječenja edema mozga u moždanom udaru, traumatskim ozljedama mozga, subarahnoidalnom krvarenju, no jedini objavljeni radovi vezani uz ulogu ovog neurokirurškog postupka u encefalitisu su prikazi slučajeva. ----- U ovom radu prikazani su slučajevi dvaju odraslih bolesnica koje su zbog herpes simpleks encefalitisa liječene u Klinici za infektivne bolesti „dr.Fran Mihaljević“, uz potvrdu dijagnoze nalazom cerebrospinalnog likvora. U obje bolesnice je bolest progredirala uz poremećaj svijesti te respiratornu insuficijenciju. Neuroradiološkom slikovnom dijagnostikom utvrđen je edem mozga koji se pogoršavao do prijeteće hernijacije mozga, kada je indicirana i učinjena dekompresijska kranijektomija. Nakon operacije je uslijedio zamjetan fizički oporavak, no u obje bolesnice su prisutni trajni neuropsihološki poremećaji. ----- Prikazi ovih slučajeva doprinose dosadašnjim saznanjima o pozitivnoj ulozi dekompresijske kranijektomije u smanjenju mortaliteta od malignog edema kao komplikacije encefalitisa. Potrebna su daljnja, veća istraživanja kako bi se jasno definirale indikacije i vrijeme postupka, kao i kriteriji za praćenje oporavka.
Abstract (english)
Herpes simplex virus is the most common cause of encephalitis, making up to 10-20% of all cases. Introduction of acyclovir into the treatment of this infectious disease significantly reduced mortality, however mortality still remains significant, mostly as a consequence of brain oedema and subsequent herniation. ----- Decompressive craniectomy has been described in the treatment of brain oedema consequential to stroke, traumatic brain injury and subarachnoid hemorrhage. In the setting of encephalitis, however, this procedure has only been described in case reports. ----- This dissertation includes case reports of two adult female patients suffering from Herpes simplex viral encephalitis, treated in University Hospital for Infectious Diseases „Fran Mihaljević“. Diagnosis was confirmed with lumbar punction results. Both patients' condition worsened with deteriorating level of consciousness and respiratory insufficiency. Neuroradiological imaging confirmed brain oedema which progressed to threatening herniation, when decompressive craniectomy was indicated and performed. Postoperatively, physical recovery was remarkable; however, both patients remain permanently psychologically impaired. ----- These two case reports contribute to the current scarce amount of published work on the positive effect decompressive craniectomy has on reducing mortality from brain oedema as a complication of encephalitis. Further, larger research is necessary to define clear indications and timing of this procedure, as well as recovery criteria.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:849419
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-04-11 10:54:52