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doctoral thesis
Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:884033
Tarle, Marko
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Tarle, M. (2023). Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:884033

Tarle, Marko. "Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:884033

Tarle, Marko. "Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:884033

Tarle, M. (2023). 'Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:884033

Tarle M. Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:884033

M. Tarle, "Izraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:884033

Metadata
TitleIzraženost jezgrina receptora epidermalnog čimbenika rasta kao biljega u premalignim i malignim promjenama usne šupljine
Title (english)Nuclear expression of epidermal growth factor receptor as a marker in premalignant and malignant changes of the oral cavity
AuthorMarko Tarle
MentorIvica Lukšić (mentor)
MentorDanko Müller (komentor)
Committee memberMartin Jurlina (predsjednik povjerenstva)
Committee memberSpomenka Manojlović (član povjerenstva)
Committee memberDavor Vagić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-04-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Cilj: Glavni cilj ovog istraživanja bio je imunohistokemijskim metodama iz uzoraka oralnih leukoplakija (OL) i eritroplakija (OE) te planocelularnih karcinoma usne šupljine (OSCC) odrediti stupanj izraženosti nEGFR-a i drugih markera staničnog ciklusa te njihov utjecaj na malignu transformaciju OL i OE kao i na kliničke ishode i prognozu bolesti oboljelih od OSCC-a. Materijali i metode: Imunohistokemijskim metodama analiziran je izražaj markera nEGFR, mEGFR, Ki-67, p53, ciklina D1 te ABCG2 u patohistološkim uzorcima 50 bolesnika s OL ili OE i 52 bolesnika s OSCC-om. Rezultati: Utvrđen je porast izražaja mEGFR i nEGFR razvojem bolesti (p<0,0001). U skupini bolesnika s OL i OE dokazali smo pozitivnu korelaciju između nEGFR-a i Ki67, p53, ciklina D1 i mEGFR, dok smo u skupini OSCC-a utvrdili pozitivnu korelaciju između nEGFR-a i Ki67, mEGFR (p<0,05). Istodobni izražaj nEGFR-a i ABCG2 povećava rizik od maligne transformacije 12,8 puta. Tumori bez perineuralne (PNI) invazije su pokazivali veću učestalost izražaja proteina p53 u odnosu na tumore s PNI (p=0,02), dok je za ABCG2 utvrđena pozitivna korelacija s istim parametrom (p=0,02). Bolesnici s OSCC-om i prekomjernim izražajem nEGFR-a imali kraće sveukupno doživljenje (p=0,004). Zaključak: Rezultati ovog istraživanja impliciraju na moguću važnu neovisnu ulogu nEGFR-a u oralnoj karcinogenezi.
Abstract (english)
Aim: The aim of this study was to determine the expression of nEGFR and other cell cycle markers and their influence on malignant transformation of oral leukoplakia (OL) and oral erythroplakia (OE) and on clinical outcomes and prognosis of patients with OSCC. Materials and methods: The expression of the markers nEGFR, mEGFR, Ki-67, p53, cyclin D1, and ABCG2 was analyzed by immunohistochemical methods in pathohistological specimens from 50 patients with OL or OE and 52 patients with OSCC. Results: An increase in the expression of mEGFR and nEGFR was found with the development of the disease (p<0.0001). In the group of patients with OL and OE we found a positive correlation between nEGFR and Ki67, p53, cyclin D1 and mEGFR, while in the group of patients with OSCC we found a positive correlation between nEGFR and Ki67, mEGFR (p<0.05). Co-expression of nEGFR and ABCG2 increased the risk of malignant transformation by 12.8-fold. Tumors without perineural (PNI) invasion had higher expression of p53 protein than tumors with PNI (p=0.02). Patients with OSCC and overexpression of nEGFR had shorter overall survival (p=0.004). Conclusion: The results of this study suggest a potentially important independent role of nEGFR in oral carcinogenesis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:884033
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent177 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-12 11:59:58