prikaz prve stranice dokumenta Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
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Scientific paper - Original scientific paper
Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
Biomedicines, 10 (2022), 12; 3118. https://doi.org/10.3390/biomedicines10123118
Babić Leko, Mirjana; Nikolac Perković, Matea; Španić, Ena; Švob Štrac, Dubravka; Pleić, Nikolina; Vogrinc, Željka; Gunjača, Ivana; Bežovan, Dora; Nedić Erjavec, Gordana; Klepac, Nataša; Borovečki, Fran; Zemunik, Tatijana; Pivac, Nela; Hof, Patrick R.; Šimić, Goran More authors...

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Babić Leko, M., Nikolac Perković, M., Španić, E., Švob Štrac, D., Pleić, N., Vogrinc, Ž. ... Šimić, G. (2022). Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123118

Babić Leko, Mirjana, et al. "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease." Biomedicines, vol. 10, no. 12, 2022. https://doi.org/10.3390/biomedicines10123118

Babić Leko, Mirjana, Matea Nikolac Perković, Ena Španić, Dubravka Švob Štrac, Nikolina Pleić, Željka Vogrinc, Ivana Gunjača, et al. "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease." Biomedicines 10, no. 12 (2022). https://doi.org/10.3390/biomedicines10123118

Babić Leko, M., et al. (2022) 'Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease', Biomedicines, 10(12). doi: 10.3390/biomedicines10123118

Babić Leko M, Nikolac Perković M, Španić E, Švob Štrac D, Pleić N, Vogrinc Ž, and sur.. Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease. Biomedicines [Internet]. 2022 December 02 [cited 2024 December 30];10(12). doi: 10.3390/biomedicines10123118

M. Babić Leko, et al., "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease", Biomedicines, vol. 10, no. 12, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:453653. [Accessed: 30 December 2024]

Metadata
Title (english)Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
AuthorMirjana Babić Leko
AuthorMatea Nikolac Perković
AuthorEna Španić
AuthorDubravka Švob Štrac
AuthorNikolina Pleić
AuthorŽeljka Vogrinc
AuthorIvana Gunjača
AuthorDora Bežovan
AuthorGordana Nedić Erjavec
AuthorNataša Klepac
AuthorFran Borovečki
AuthorTatijana Zemunik
AuthorNela Pivac
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
A decrease in serotonergic transmission throughout the brain is among the earliest pathological changes in Alzheimer’s disease (AD). Serotonergic receptors are also affected in AD. Polymorphisms in genes of serotonin (5HT) receptors have been mostly associated with behavioral and psychological symptoms of dementia (BPSD). In this study, we examined if AD patients carrying different genotypes in 5HTR1B rs13212041, 5HTR2A rs6313 (T102C), 5HTR2C rs3813929 (−759C/T), and 5HTR6 rs1805054 (C267T) polymorphisms have a higher risk of faster disease progression (assessed by neuropsychological testing), are more prone to develop AD-related pathology (reflected by levels of cerebrospinal fluid [CSF] AD biomarkers), or have an association with an apolipoprotein E (APOE) haplotype. This study included 115 patients with AD, 53 patients with mild cognitive impairment (MCI), and 2701 healthy controls. AD biomarkers were determined in the CSF of AD and MCI patients using enzyme-linked immunosorbent assays (ELISA), while polymorphisms were determined using either TaqMan SNP Genotyping Assays or Illumina genotyping platforms. We detected a significant decrease in the CSF amyloid β1–42 (Aβ1–42) and an increase in p-tau181/Aβ1–42 ratio in carriers of the T allele in the 5HTR2C rs3813929 (−759C/T) polymorphism. A significantly higher number of APOE ε4 allele carriers was observed among individuals carrying a TT genotype within the 5HTR2A T102C polymorphism, a C allele within the 5HTR1B rs13212041 polymorphism, and a T allele within the 5HTR6 rs1805054 (C267T) polymorphism. Additionally, individuals carrying the C allele within the 5HTR1B rs13212041 polymorphism were significantly more represented among AD patients and had poorer performances on the Rey–Osterrieth test. Carriers of the T allele within the 5HTR6 rs1805054 had poorer performances on the MMSE and ADAS–Cog. As all four analyzed polymorphisms of serotonin receptor genes showed an association with either genetic, CSF, or neuropsychological biomarkers of AD, they deserve further investigation as potential early genetic biomarkers of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 12, 3118
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123118
URN:NBNurn:nbn:hr:105:453653
Publication2022-12-02
ProjectNumber: IP-2019-04-3584
Title (croatian): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Title (english): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Acronym: ALZ-BBB-INNATETAU
Leader: Goran Šimić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2014-09-9730
Title (croatian): Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva
Title (english): Tau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer's disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds
Acronym: ALZTAUPROTECT
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2019-04-2593
Title (croatian): Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi
Title (english): Regulation of thyroid and parathyroid function and blood calcium homeostasis
Acronym: THPTHCAREGULATION
Leader: Tatijana Zemunik
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2227-9059/10/12/3118
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-15 10:42:16