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Scientific paper - Original scientific paper
Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?
Biomedicines, 10 (2022), 12; 3014. https://doi.org/10.3390/biomedicines10123014
Šamadan, Lara; Papić, Neven; Mijić, Maja; Knežević Štromar, Ivana; Gašparov, Slavko; Vince, Adriana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Šamadan, L., Papić, N., Mijić, M., Knežević Štromar, I., Gašparov, S. & Vince, A. (2022). Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123014

Šamadan, Lara, et al. "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?." Biomedicines, vol. 10, no. 12, 2022. https://doi.org/10.3390/biomedicines10123014

Šamadan, Lara, Neven Papić, Maja Mijić, Ivana Knežević Štromar, Slavko Gašparov and Adriana Vince. "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?." Biomedicines 10, no. 12 (2022). https://doi.org/10.3390/biomedicines10123014

Šamadan, L., et al. (2022) 'Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?', Biomedicines, 10(12). doi: 10.3390/biomedicines10123014

Šamadan L, Papić N, Mijić M, Knežević Štromar I, Gašparov S, Vince A. Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?. Biomedicines [Internet]. 2022 November 23 [cited 2024 May 03];10(12). doi: 10.3390/biomedicines10123014

L. Šamadan, N. Papić, M. Mijić, I. Knežević Štromar, S. Gašparov and A. Vince, "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?", Biomedicines, vol. 10, no. 12, November 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:444120. [Accessed: 03 May 2024]

Metadata
Title (english)Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?
AuthorLara Šamadan
AuthorNeven Papić
AuthorMaja Mijić
AuthorIvana Knežević Štromar
AuthorSlavko Gašparov
AuthorAdriana Vince
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression. Semaphorins, a large family of biological response modifiers, were recently recognized as one of the key regulators of immune responses, possibly also associated with chronic liver diseases. The aim of this study was to identify semaphorins associated with NAFLD and their relationship with steatosis and fibrosis stages. In this prospective, case-control study, serum semaphorin concentrations (SEMA3A, -3C, -4A, -4D, -5A and -7A) were measured in 95 NAFLD patients and 35 healthy controls. Significantly higher concentrations of SEMA3A, -3C and -4D and lower concentrations of SEAMA5A and -7A were found in NAFLD. While there was no difference according to steatosis grades, SEMA3C and SEMA4D significantly increased and SEMA3A significantly decreased with fibrosis stages and had better accuracy in predicting fibrosis compared to the FIB-4 score. Immunohistochemistry confirmed higher expression of SEMA4D in hepatocytes, endothelial cells and lymphocytes in NAFLD livers. The SEMA5A rs1319222 TT genotype was more frequent in the NAFLD group and was associated with higher liver stiffness measurements. In conclusion, we provide the first evidence of the association of semaphorins with fibrosis in patients with NAFLD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 12, 3014
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123014
URN:NBNurn:nbn:hr:105:444120
Publication2022-11-23
ProjectNumber: UIP-2019-04-7194
Title (croatian): Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi
Title (english): The role of immune semaphorins in NAFLD and sepsis
Acronym: SepsisFAT
Leader: Neven Papić
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://www.mdpi.com/2227-9059/10/12/3014
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-15 10:49:25