prikaz prve stranice dokumenta Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience
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Scientific paper - Original scientific paper
Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience
World Journal of Transplantation, 12 (2022), 11; 378-387. https://doi.org/10.5500/wjt.v12.i11.378
Šimunov, Bojana; Mrzljak, Anna; Jurekovič, Željka; Židovec Lepej, Snježana; Bainrauch, Ana; Pavičić Šarić, Jadranka; Hruskar, Željka; Radmanić, Leona; Vilibić-Čavlek, Tatjana

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Šimunov, B., Mrzljak, A., Jurekovič, Ž., Židovec Lepej, S., Bainrauch, A., Pavičić Šarić, J. ... Vilibić Čavlek, T. (2022). Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience. World Journal of Transplantation, 12. (11), 378-387. doi: 10.5500/wjt.v12.i11.378

Šimunov, Bojana, et al. "Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience." World Journal of Transplantation, vol. 12, no. 11, 2022, pp. 378-387. https://doi.org/10.5500/wjt.v12.i11.378

Šimunov, Bojana, Anna Mrzljak, Željka Jurekovič, Snježana Židovec Lepej, Ana Bainrauch, Jadranka Pavičić Šarić, Željka Hruskar, Leona Radmanić and Tatjana Vilibić Čavlek. "Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience." World Journal of Transplantation 12, no. 11 (2022): 378-387. https://doi.org/10.5500/wjt.v12.i11.378

Šimunov, B., et al. (2022) 'Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience', World Journal of Transplantation, 12(11), pp. 378-387. doi: 10.5500/wjt.v12.i11.378

Šimunov B, Mrzljak A, Jurekovič Ž, Židovec Lepej S, Bainrauch A, Pavičić Šarić J, and sur.. Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience. World Journal of Transplantation [Internet]. 2022 November 18 [cited 2025 April 06];12(11):378-387. doi: 10.5500/wjt.v12.i11.378

B. Šimunov, et al., "Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience", World Journal of Transplantation, vol. 12, no. 11, pp. 378-387, November 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:397186. [Accessed: 06 April 2025]

Metadata
Title (english)Parvovirus B19 status in liver, kidney and pancreas transplant candidates: A single center experience
AuthorBojana Šimunov
AuthorAnna Mrzljak
AuthorŽeljka Jurekovič
AuthorSnježana Židovec Lepej
AuthorAna Bainrauch
AuthorJadranka Pavičić Šarić
AuthorŽeljka Hruskar
AuthorLeona Radmanić
AuthorTatjana Vilibić-Čavlek
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Background: Parvovirus B19 (B19V) is associated with a wide range of clinical manifestations. The major presentation is erythema infectiosum. However, a persistent infection may cause pure red cell aplasia and chronic anemia in immunocompromized patients. The B19V seroprevalence varies with age and geographical location. Aim: To determine the B19V serological status and DNAemia in kidney, liver, and pancreas transplant candidates. Methods: Patients who underwent kidney, liver, or... More simultaneous kidney and pancreas/liver transplantation between January 2021 and May 2022 were included in the study. The serum samples were collected before transplantation. For detection of B19V DNA, a LightMix Kit B19V EC (TIB MOLBIOL, Berlin, Germany) was used. B19V IgM and IgG antibodies were detected using a commercial ELISA test (Euroimmun, Lübeck, Germany). Results: One hundred and thirty-one transplant candidates were included in the study, 71.0% male, with an average age of 53.27 years ± 12.71 years. There were 68.7% liver, 27.5% kidney, 3.0% simul taneous pancreas/kidney transplant (SPKT), and 0.8% simultaneous liver/kidney transplant recipients. No patients had detectable B19V DNA. B19V IgG seroprevalence was 77.1%. No acute or recent infections were detected (IgM antibodies). There was no difference in the mean age of seronegative and seropositive patients (51.8 years ± 12.9 years vs 53.7 years ± 12.7 years, t = -0.603; P = 0.548). Although seropositivity was lower in patients aged less than 30 years (66.6%) compared to the patients aged 30-59 years and > 60 years (80.4% and 78.1%, respectively), this difference was not significant. In addition, there was no difference in seropositivity between male and female transplant candidates, 76.3% and 78.9% (χ 2 = 0.104; P = 0.748). The seroprevalence did not differ among organ recipients, with 77.8%, 80.6%, and 50.0% for liver, kidney, and SPKT, respectively, (χ 2 = 5.297; P = 0.151). No significant difference was found in the seroprevalence in kidney transplant patients according to dialysis modality. Seroprevalence was 71.1% in hemodialysis patients, and 100% in peritoneal dialysis patients (χ 2 = 0.799; P = 0.372). Conclusion: The B19V seroprevalence is expectedly high among kidney, liver, and pancreas transplant candidates, but there are still 22.9% of seronegative individuals who remain at risk for primary disease and severe manifestations. Further research should elucidate the necessity of B19V screening in peri-transplant management. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Transplantation
Numberingvol. 12, no. 11, pp. 378-387
p-ISSN2220-3230
DOIhttps://doi.org/10.5500/wjt.v12.i11.378
URN:NBNurn:nbn:hr:105:397186
Publication2022-11-18
Document URLhttps://www.wjgnet.com/2220-3230/full/v12/i11/378.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-06-12 09:01:00
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