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doctoral thesis
Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:002205
Čolić, Ana
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Čolić, A. (2023). Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:002205

Čolić, Ana. "Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:002205

Čolić, Ana. "Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:002205

Čolić, A. (2023). 'Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi', Doctoral thesis, University of Zagreb, School of Medicine, accessed 27 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:002205

Čolić A. Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 April 27] Available at: https://urn.nsk.hr/urn:nbn:hr:105:002205

A. Čolić, "Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:002205

Metadata
TitlePovezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi
Title (english)The association between the weight gain acceleration and the retinopathy of prematurity phase two
AuthorAna Čolić
MentorNenad Vukojević (mentor)
Committee memberBoris Filipović-Grčić (predsjednik povjerenstva)
Committee memberTomislav Jukić (član povjerenstva)
Committee memberSnježana Kaštelan (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-07-03, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Prijevremeni porod odgađa normalnu vaskularizaciju retine koja se nastavlja abnormalnim rastom krvnog žilja u drugoj fazi retinopatije nedonoščadi. U nedonoščeta karakterističan je spori postnatalni prirast tjelesne mase sa slijedom nadoknade rasta. Cilj ovog istraživanja bilo je dokazati da je ubrzanje prirasta tjelesne mase praćeno pojavom druge faze ROP-a. Ispitivanu skupinu čini 52 nedonoščeta GD ≤ 28 tjedana i RM ≤ 1250 grama odabranih prema čimbenicima rizika za razvoj ROPa te isključnih utjecaja na prirast tjelesne mase. Retrospektivnom studijom utvrđeno je ubrzanje prirasta tjelesne mase te analizirana povezanost s pojavom druge faze ROP-a. Medijan PMD početka ubrzanja prirasta tjelesne mase je 32 tjedna. Nije zabilježena pojava ROP-a prije ubrzanja a prva pojava ROP-a zabilježena je tjedan dana po početku ubrzanja prirasta tjelesne mase u 40.4 % ispitanika. U ukupno 44.3 % slučajeva ROP se pojavljuje u drugom i trećem tjednu po ubrzanju sa smanjenjem pojavnosti u slijedećim tjednima. Dokazali smo povezanost ubrzanja prirasta tjelesne mase i druge proliferativne faze ROP-a čime smo pridonijeli saznanjima o patogenezi ove bolesti s mogućnošću primjene u kliničkoj praksi. Započinjanjem probira za ROP po utvrđivanju ubrzanja smanjio bi se broj izlaganja nedonoščadi proceduralnom stresu oftalmološkog pregleda.
Abstract (english)
Premature birth delays normal vascularization that continues with abnormal blood vessels growth in ROP phase two. In premature infants slow postnatal weight gain is followed by catch-up growth. The aim of this research was to prove that weight gain acceleration is associated with emergence of ROP phase two. 52 premature infants GA ≤ 28 weeks and BW ≤ 1250 grams were selected according to risk factors for the ROP development and exclusive effects on weight gain. By retrospective study the acceleration of weight gain is determined and the association with occurrence of the second phase of ROP was analyzed. The median PMA of the onset of weight gain acceleration is 32 weeks. No ROP was recorded before the acceleration, and ROP occured a week after the start of the acceleration in 40.4 % of subjects. Sum of occurrence for second and third week was 44.3 % with decrease of incidence in the following weeks. We proved the connection between the weight gain acceleration and the second phase of ROP, contributing to the knowledge on ROP pathogenesis with possible clinical application. Initiating screening for ROP after acceleration might reduce exposures of premature infants to the procedural stress of the ophtalmic examination.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:002205
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent83 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-07 12:21:25