prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
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Scientific paper - Original scientific paper
Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
Biomedicines, 10 (2022), 11; 2696. https://doi.org/10.3390/biomedicines10112696
Sikirić, Predrag; Udovičić, Mario; Barišić, Ivan; Balenović, Diana; Živanović Posilović, Gordana; Strinić, Dean; Uzun, Sandra; Sikirić, Sunčana; Krezić, Ivan; Žižek, Helena; Yago, Haidi; Gojković, Slaven; Smoday, Ivan Maria; Kalogjera, Luka; Vraneš, Hrvoje; Sola, Marija; Štrbe, Sanja; Koprivanac, Antun; Premužić Meštrović, Ivica; Meštrović, Tomislav; Pavić, Predrag; Škrtić, Anita; Boban Blagaić, Alenka; Lovrić Benčić, Martina; Seiwerth, Sven More authors...

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Sikirić, P., Udovičić, M., Barišić, I., Balenović, D., Živanović Posilović, G., Strinić, D. ... Seiwerth, S. (2022). Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. Biomedicines, 10. (11). doi: 10.3390/biomedicines10112696

Sikirić, Predrag, et al. "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation." Biomedicines, vol. 10, no. 11, 2022. https://doi.org/10.3390/biomedicines10112696

Sikirić, Predrag, Mario Udovičić, Ivan Barišić, Diana Balenović, Gordana Živanović Posilović, Dean Strinić, Sandra Uzun, et al. "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation." Biomedicines 10, no. 11 (2022). https://doi.org/10.3390/biomedicines10112696

Sikirić, P., et al. (2022) 'Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation', Biomedicines, 10(11). doi: 10.3390/biomedicines10112696

Sikirić P, Udovičić M, Barišić I, Balenović D, Živanović Posilović G, Strinić D, and sur.. Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. Biomedicines [Internet]. 2022 October 25 [cited 2024 April 28];10(11). doi: 10.3390/biomedicines10112696

P. Sikirić, et al., "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation", Biomedicines, vol. 10, no. 11, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:861048. [Accessed: 28 April 2024]

Metadata
Title (english)Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
AuthorPredrag Sikirić
AuthorMario Udovičić
AuthorIvan Barišić
AuthorDiana Balenović
AuthorGordana Živanović Posilović
AuthorDean Strinić
AuthorSandra Uzun
AuthorSunčana Sikirić
AuthorIvan Krezić
AuthorHelena Žižek
AuthorHaidi Yago
AuthorSlaven Gojković
AuthorIvan Maria Smoday
AuthorLuka Kalogjera
AuthorHrvoje Vraneš
AuthorMarija Sola
AuthorSanja Štrbe
MBZ: 319335
AuthorAntun Koprivanac
AuthorIvica Premužić Meštrović
AuthorTomislav Meštrović
AuthorPredrag Pavić
AuthorAnita Škrtić
AuthorAlenka Boban Blagaić
AuthorMartina Lovrić Benčić
AuthorSven Seiwerth
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
In heart disturbances, stable gastric pentadecapeptide BPC 157 especial therapy effects combine the therapy of myocardial infarction, heart failure, pulmonary hypertension arrhythmias, and thrombosis prevention and reversal. The shared therapy effect occurred as part of its even larger cytoprotection (cardioprotection) therapy effect (direct epithelial cell protection; direct endothelium cell protection) that BPC 157 exerts as a novel cytoprotection mediator, which is native and stable in human gastric juice, as well as easily applicable. Accordingly, there is interaction with many molecular pathways, combining maintained endothelium function and maintained thrombocytes function, which counteracted thrombocytopenia in rats that underwent major vessel occlusion and deep vein thrombosis and counteracted thrombosis in all vascular studies; the coagulation pathways were not affected. These appeared as having modulatory effects on NO-system (NO-release, NOS-inhibition, NO-over-stimulation all affected), controlling vasomotor tone and the activation of the Src-Caveolin-1-eNOS pathway and modulatory effects on the prostaglandins system (BPC 157 counteracted NSAIDs toxicity, counteracted bleeding, thrombocytopenia, and in particular, leaky gut syndrome). As an essential novelty noted in the vascular studies, there was the activation of the collateral pathways. This might be the upgrading of the minor vessel to take over the function of the disabled major vessel, competing with and counteracting the Virchow triad circumstances devastatingly present, making possible the recruitment of collateral blood vessels, compensating vessel occlusion and reestablishing the blood flow or bypassing the occluded or ruptured vessel. As a part of the counteraction of the severe vessel and multiorgan failure syndrome, counteracted were the brain, lung, liver, kidney, gastrointestinal lesions, and in particular, the counteraction of the heart arrhythmias and infarction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 11, 2696
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10112696
URN:NBNurn:nbn:hr:105:861048
Publication2022-10-25
Document URLhttps://www.mdpi.com/2227-9059/10/11/2696
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-07-13 07:58:48