prikaz prve stranice dokumenta Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
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Scientific paper - Original scientific paper
Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
Biomolecules, 12 (2022), 10; 1542. https://doi.org/10.3390/biom12101542
Degoricija, Vesna; Klobučar, Iva; Potočnjak, Ines; Dokoza Terešak, Sanda; Vidović, Luka; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Frank, Saša

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Degoricija, V., Klobučar, I., Potočnjak, I., Dokoza Terešak, S., Vidović, L., Pregartner, G. ... Frank, S. (2022). Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients. Biomolecules, 12. (10). doi: 10.3390/biom12101542

Degoricija, Vesna, et al. "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients." Biomolecules, vol. 12, no. 10, 2022. https://doi.org/10.3390/biom12101542

Degoricija, Vesna, Iva Klobučar, Ines Potočnjak, Sanda Dokoza Terešak, Luka Vidović, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl and Saša Frank. "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients." Biomolecules 12, no. 10 (2022). https://doi.org/10.3390/biom12101542

Degoricija, V., et al. (2022) 'Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients', Biomolecules, 12(10). doi: 10.3390/biom12101542

Degoricija V, Klobučar I, Potočnjak I, Dokoza Terešak S, Vidović L, Pregartner G, and sur.. Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients. Biomolecules [Internet]. 2022 October 21 [cited 2024 May 07];12(10). doi: 10.3390/biom12101542

V. Degoricija, et al., "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients", Biomolecules, vol. 12, no. 10, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:940839. [Accessed: 07 May 2024]

Metadata
Title (english)Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
AuthorVesna Degoricija
AuthorIva Klobučar
AuthorInes Potočnjak
AuthorSanda Dokoza Terešak
AuthorLuka Vidović
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorHansjörg Habisch
AuthorTobias Madl
AuthorSaša Frank
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Considering the relationship between the extent of metabolic derangement and the disease severity in heart failure, we hypothesized that the lipid content of very-low-density lipoprotein (VLDL) may have prognostic value for 1 year mortality in acute heart failure (AHF). Baseline serum levels of VLDL cholesterol (VLDL-C), VLDL triglycerides (VLDL-TG), VLDL phospholipids (VLDL-PL), and VLDL apolipoprotein B (VLDL-apoB) were measured using NMR spectroscopy. We calculated the ratios of the respective VLDL lipids and VLDL apoB (VLDL-C/VLDL-apoB, VLDL-TG/VLDL-apoB, and VLDL-PL/VLDL-apoB), as estimators of the cholesterol, triglyceride, and phospholipid content of VLDL particles and tested their association with mortality. Out of 315 AHF patients, 118 (37.5%) patients died within 1 year after hospitalization for AHF. Univariable Cox regression analyses revealed a significant inverse association of VLDL-C/VLDL-apoB (hazard ratio (HR) 0.43, 95% confidence interval (CI) 0.29–0.64, p < 0.001), VLDL-TG/VLDL-apoB (HR 0.79, 95% CI 0.71–0.88, p < 0.001), and VLDL-PL/VLDL-apoB (HR 0.37, 95% CI 0.25–0.56, p < 0.001) with 1 year mortality. Of the tested parameters, only VLDL-C/VLDL-apoB remained significant after adjustment for age and sex, as well as other clinical and laboratory parameters that showed a significant association with 1 year mortality in the univariable analyses. We conclude that cholesterol content of circulating VLDL (VLDL-C/VLDL-apoB) might be of prognostic value in AHF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 12, no. 10, 1542
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12101542
URN:NBNurn:nbn:hr:105:940839
Publication2022-10-21
Document URLhttps://www.mdpi.com/2218-273X/12/10/1542
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-21 07:52:01