prikaz prve stranice dokumenta Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital
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Scientific paper - Original scientific paper
Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital
International Journal of Molecular Sciences, 23 (2022), 19; 11810. https://doi.org/10.3390/ijms231911810
Žarković, Neven; Łuczaj, Wojciech; Jarocka-Karpowicz, Iwona; Orehovec, Biserka; Baršić, Bruno; Tarle, Marko; Kmet, Marta; Lukšić, Ivica; Biernacki, Michał; Skrzydlewska, Elżbieta

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Žarković, N., Łuczaj, W., Jarocka Karpowicz, I., Orehovec, B., Baršić, B., Tarle, M. ... Skrzydlewska, E. (2022). Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. International Journal of Molecular Sciences, 23. (19). doi: 10.3390/ijms231911810

Žarković, Neven, et al. "Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital." International Journal of Molecular Sciences, vol. 23, no. 19, 2022. https://doi.org/10.3390/ijms231911810

Žarković, Neven, Wojciech Łuczaj, Iwona Jarocka Karpowicz, Biserka Orehovec, Bruno Baršić, Marko Tarle, Marta Kmet, Ivica Lukšić, Michał Biernacki and Elżbieta Skrzydlewska. "Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital." International Journal of Molecular Sciences 23, no. 19 (2022). https://doi.org/10.3390/ijms231911810

Žarković, N., et al. (2022) 'Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital', International Journal of Molecular Sciences, 23(19). doi: 10.3390/ijms231911810

Žarković N, Łuczaj W, Jarocka Karpowicz I, Orehovec B, Baršić B, Tarle M, and sur.. Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. International Journal of Molecular Sciences [Internet]. 2022 October 05 [cited 2024 December 26];23(19). doi: 10.3390/ijms231911810

N. Žarković, et al., "Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital", International Journal of Molecular Sciences, vol. 23, no. 19, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:371575. [Accessed: 26 December 2024]

Metadata
Title (english)Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital
AuthorNeven Žarković
AuthorWojciech Łuczaj
AuthorIwona Jarocka-Karpowicz
AuthorBiserka Orehovec
AuthorBruno Baršić
AuthorMarko Tarle
AuthorMarta Kmet
AuthorIvica Lukšić
AuthorMichał Biernacki
AuthorElżbieta Skrzydlewska
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
As a result of SARS-CoV-2 infection, inflammation develops, which promotes oxidative stress, leading to modification of phospholipid metabolism. Therefore, the aim of this study is to compare the effects of COVID-19 on the levels of phospholipid and free polyunsaturated fatty acids (PUFAs) and their metabolites produced in response to reactions with reactive oxygen species (ROS) and enzymes (cyclooxygenases-(COXs) and lipoxygenase-(LOX)) in the plasma of patients who either recovered or passed away within a week of hospitalization. In the plasma of COVID-19 patients, especially of the survivors, the actions of ROS and phospholipase A2 (PLA2) cause a decrease in phospholipid fatty acids level and an increase in free fatty acids (especially arachidonic acid) despite increased COXs and LOX activity. This is accompanied by an increased level in lipid peroxidation products (malondialdehyde and 8-isoprostaglandin F2α) and lipid mediators generated by enzymes. There is also an increase in eicosanoids, both pro-inflammatory as follows: thromboxane B2 and prostaglandin E2, and anti-inflammatory as follows: 15-deoxy-Δ-12,14-prostaglandin J2 and 12-hydroxyeicosatetraenoic acid, as well as endocannabinoids (anandamide-(AEA) and 2-arachidonylglycerol-(2-AG)) observed in the plasma of patients who recovered. Moreover, the expression of tumor necrosis factor α and interleukins (IL-6 and IL-10) is increased in patients who recovered. However, in the group of patients who died, elevated levels of N-oleoylethanolamine and N-palmitoylethanolamine are found. Since lipid mediators may have different functions depending on the onset of pathophysiological processes, a stronger pro-inflammatory response in patients who have recovered may be the result of the defensive response to SARS-CoV-2 in survivors associated with specific changes in the phospholipid metabolism, which could also be considered a prognostic factor.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 19, 11810
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms231911810
URN:NBNurn:nbn:hr:105:371575
Publication2022-10-05
Document URLhttps://www.mdpi.com/1422-0067/23/19/11810
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-22 08:40:04