prikaz prve stranice dokumenta Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
  Download
PDF 2.59 MB
Scientific paper - Original scientific paper
Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
International Journal of Molecular Sciences, 23 (2022), 19; 11626. https://doi.org/10.3390/ijms231911626
Šoštarić, Petra; Vukić, Barbara; Tomašić, Lea; Matak, Ivica

Linked objects
Article Šoštarić et al. 2022 International Journal of Molecular Sciences | Dataset

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šoštarić, P., Vukić, B., Tomašić, L. & Matak, I. (2022). Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats. International Journal of Molecular Sciences, 23. (19). doi: 10.3390/ijms231911626

Šoštarić, Petra, et al. "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats." International Journal of Molecular Sciences, vol. 23, no. 19, 2022. https://doi.org/10.3390/ijms231911626

Šoštarić, Petra, Barbara Vukić, Lea Tomašić and Ivica Matak. "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats." International Journal of Molecular Sciences 23, no. 19 (2022). https://doi.org/10.3390/ijms231911626

Šoštarić, P., et al. (2022) 'Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats', International Journal of Molecular Sciences, 23(19). doi: 10.3390/ijms231911626

Šoštarić P, Vukić B, Tomašić L, Matak I. Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats. International Journal of Molecular Sciences [Internet]. 2022 October 01 [cited 2024 May 05];23(19). doi: 10.3390/ijms231911626

P. Šoštarić, B. Vukić, L. Tomašić and I. Matak, "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats", International Journal of Molecular Sciences, vol. 23, no. 19, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:343506. [Accessed: 05 May 2024]

Metadata
Title (english)Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
AuthorPetra Šoštarić
AuthorBarbara Vukić
AuthorLea Tomašić
AuthorIvica Matak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Recent animal experiments suggested that centrally transported botulinum toxin type A (BoNT-A) might reduce an abnormal muscle tone, though with an unknown contribution to the dominant peripheral muscular effect observed clinically. Herein, we examined if late BoNT-A antispastic actions persist due to possible central toxin actions in rats. The early effect of intramuscular (i.m.) BoNT-A (5, 2 and 1 U/kg) on a reversible tetanus toxin (TeNT)-induced calf muscle spasm was examined 7 d post-TeNT and later during recovery from flaccid paralysis (TeNT reinjected on day 49 post-BoNT-A). Lumbar intrathecal (i.t.) BoNT-A–neutralizing antiserum was used to discriminate the transcytosis-dependent central toxin action of 5 U/kg BoNT-A. BoNT-A-truncated synaptosomal-associated protein 25 immunoreactivity was examined in the muscles and spinal cord at day 71 post-BoNT-A. All doses (5, 2 and 1 U/kg) induced similar antispastic actions in the early period (days 1–14) post-BoNT-A. After repeated TeNT, only the higher two doses prevented the muscle spasm and associated locomotor deficit. Central trans-synaptic activity contributed to the late antispastic effect of 5 U/kg BoNT-A. Ongoing BoNT-A enzymatic activity was present in both injected muscle and the spinal cord. These observations suggest that the treatment duration in sustained or intermittent muscular hyperactivity might be maintained by higher doses and combined peripheral and central BoNT-A action.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 19, 11626
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms231911626
URN:NBNurn:nbn:hr:105:343506
Publication2022-10-01
ProjectNumber: UIP-2019-04-8277
Title (croatian): Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu
Title (english): Motor effects of clostridial neurotoxins in central nervous system
Acronym: MEFCLO
Leader: Ivica Matak
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://www.mdpi.com/1422-0067/23/19/11626
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-22 08:48:51