prikaz prve stranice dokumenta Upper cortical layer–driven network impairment in schizophrenia
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Scientific paper - Original scientific paper
Upper cortical layer–driven network impairment in schizophrenia
Science Advances, 8 (2022), 41; eabn8367. https://doi.org/10.1126/sciadv.abn8367
Batiuk, Mykhailo Y.; Tyler, Teadora; Dragicevic, Katarina; Mei, Shenglin; Rydbirk, Rasmus; Petukhov, Viktor; Deviatiiarov, Ruslan; Sedmak, Dora; Frank, Erzsebet; Feher, Virginia; Habek, Nikola; Hu, Qiwen; Igolkina, Anna; Roszik, Lilla; Pfisterer, Ulrich; Garcia-Gonzalez, Diego; Petanjek, Zdravko; Adorjan, Istvan; Kharchenko, Peter V.; Khodosevich, Konstantin More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Batiuk, M. Y., Tyler, T., Dragicevic, K., Mei, S., Rydbirk, R., Petukhov, V. ... Khodosevich, K. (2022). Upper cortical layer–driven network impairment in schizophrenia. Science Advances, 8. (41). doi: 10.1126/sciadv.abn8367

Batiuk, Mykhailo Y., et al. "Upper cortical layer–driven network impairment in schizophrenia." Science Advances, vol. 8, no. 41, 2022. https://doi.org/10.1126/sciadv.abn8367

Batiuk, Mykhailo Y., Teadora Tyler, Katarina Dragicevic, Shenglin Mei, Rasmus Rydbirk, Viktor Petukhov, Ruslan Deviatiiarov, et al. "Upper cortical layer–driven network impairment in schizophrenia." Science Advances 8, no. 41 (2022). https://doi.org/10.1126/sciadv.abn8367

Batiuk, M. Y., et al. (2022) 'Upper cortical layer–driven network impairment in schizophrenia', Science Advances, 8(41). doi: 10.1126/sciadv.abn8367

Batiuk MY, Tyler T, Dragicevic K, Mei S, Rydbirk R, Petukhov V, and sur.. Upper cortical layer–driven network impairment in schizophrenia. Science Advances [Internet]. 2022 October 14 [cited 2024 May 02];8(41). doi: 10.1126/sciadv.abn8367

M. Y. Batiuk, et al., "Upper cortical layer–driven network impairment in schizophrenia", Science Advances, vol. 8, no. 41, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:697862. [Accessed: 02 May 2024]

Metadata
Title (english)Upper cortical layer–driven network impairment in schizophrenia
AuthorMykhailo Y. Batiuk
AuthorTeadora Tyler
AuthorKatarina Dragicevic
AuthorShenglin Mei
AuthorRasmus Rydbirk
AuthorViktor Petukhov
AuthorRuslan Deviatiiarov
AuthorDora Sedmak
AuthorErzsebet Frank
AuthorVirginia Feher
AuthorNikola Habek
AuthorQiwen Hu
AuthorAnna Igolkina
AuthorLilla Roszik
AuthorUlrich Pfisterer
AuthorDiego Garcia-Gonzalez
AuthorZdravko Petanjek
AuthorIstvan Adorjan
AuthorPeter V. Kharchenko
AuthorKonstantin Khodosevich
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Schizophrenia is one of the most widespread and complex mental disorders. To characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) of >220,000 neurons from the dorsolateral prefrontal cortex of patients with schizophrenia and matched controls. In addition, >115,000 neurons were analyzed topographically by immunohistochemistry. Compositional analysis of snRNA-seq data revealed a reduction in abundance of GABAergic neurons and a concomitant increase in principal neurons, most pronounced for upper cortical layer subtypes, which was substantiated by histological analysis. Many neuronal subtypes showed extensive transcriptomic changes, the most marked in upper-layer GABAergic neurons, including down-regulation in energy metabolism and up-regulation in neurotransmission. Transcription factor network analysis demonstrated a developmental origin of transcriptomic changes. Last, Visium spatial transcriptomics further corroborated upper-layer neuron vulnerability in schizophrenia. Overall, our results point toward general network impairment within upper cortical layers as a core substrate associated with schizophrenia symptomatology.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScience Advances
Numberingvol. 8, no. 41, eabn8367
e-ISSN2375-2548
DOIhttps://doi.org/10.1126/sciadv.abn8367
URN:NBNurn:nbn:hr:105:697862
Publication2022-10-14
Document URLhttps://www.science.org/doi/10.1126/sciadv.abn8367
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-08-23 08:32:14