prikaz prve stranice dokumenta In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics
Embargo period 2024-06-01
Scientific paper - Original scientific paper
In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics
Journal of Chemotherapy, 35 (2022), 3; 219-230. https://doi.org/10.1080/1120009X.2022.2108247
Slade-Vitković, Mia; Bedenić, Branka; Bielen, Luka; Batarilo, Ivanka; Kibel, Sara; Maravić-Vlahoviček, Gordana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Slade Vitković, M., Bedenić, B., Bielen, L., Batarilo, I., Kibel, S. & Maravić Vlahoviček, G. (2022). In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics. Journal of Chemotherapy, 35. (3), 219-230. doi: 10.1080/1120009X.2022.2108247

Slade Vitković, Mia, et al. "In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics." Journal of Chemotherapy, vol. 35, no. 3, 2022, pp. 219-230. https://doi.org/10.1080/1120009X.2022.2108247

Slade Vitković, Mia, Branka Bedenić, Luka Bielen, Ivanka Batarilo, Sara Kibel and Gordana Maravić Vlahoviček. "In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics." Journal of Chemotherapy 35, no. 3 (2022): 219-230. https://doi.org/10.1080/1120009X.2022.2108247

Slade Vitković, M., et al. (2022) 'In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics', Journal of Chemotherapy, 35(3), pp. 219-230. doi: 10.1080/1120009X.2022.2108247

Slade Vitković M, Bedenić B, Bielen L, Batarilo I, Kibel S, Maravić Vlahoviček G. In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics. Journal of Chemotherapy [Internet]. 2022 August 09 [cited 2024 April 28];35(3):219-230. doi: 10.1080/1120009X.2022.2108247

M. Slade Vitković, B. Bedenić, L. Bielen, I. Batarilo, S. Kibel and G. Maravić Vlahoviček, "In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics", Journal of Chemotherapy, vol. 35, no. 3, pp. 219-230, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:219949. [Accessed: 28 April 2024]

Metadata
Title (english)In vitro killing of multidrug/extensively drug-resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics
AuthorMia Slade-Vitković
AuthorBranka Bedenić
AuthorLuka Bielen
AuthorIvanka Batarilo
AuthorSara Kibel
AuthorGordana Maravić-Vlahoviček
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Pseudomonas aeruginosa is a leading cause of nosocomial infections. Given the constant rise in resistance, adequate therapy is increasingly demanding. Fosfomycin recently became an appealing treatment option of bacterial infections due to multidrug-resistant bacteria (MDR). So far, fosfomycin synergy with other antibiotics has been assessed in studies, but only a limited number focused on MDR P. aeruginosa and on the effect of these combinations on the duration of the postantibiotic effect (PAE). We investigated synergy of fosfomycin with an array of antipseudomonal antibiotics using gradient diffusion strip cross method and time-kill method, and their effect on the duration of PAE against 51 variously resistant P. aeruginosa isolates. The highest rate of synergy was observed for combination with ceftazidime (23.4%) and gentamicin (19.1%). The PAE of antibiotic combinations was superior to that of the drugs alone. Our findings indicate that fosfomycin combination therapy may be a valuable treatment alternative.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Chemotherapy
Numberingvol. 35, no. 3, pp. 219-230
p-ISSN1120-009X
e-ISSN1973-9478
DOIhttps://doi.org/10.1080/1120009X.2022.2108247
URN:NBNurn:nbn:hr:105:219949
Publication2022-08-09
Document URLhttps://www.tandfonline.com/doi/full/10.1080/1120009X.2022.2108247
Type of resourceText
Access conditionsEmbargoed access
Embargo expiration date: 2024-06-01
Terms of useLicence In copyright icon
Created on2023-08-28 08:13:27