prikaz prve stranice dokumenta Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review
  Download
PDF 797.4 KB
master's thesis
Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:237809
Papič, Peter
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Papič, P. (2023). Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:237809

Papič, Peter. "Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:237809

Papič, Peter. "Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:237809

Papič, P. (2023). 'Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review', Master's thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:237809

Papič P. Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:237809

P. Papič, "Heterotopic ossifications in patients post SARS-CoV infection: case report and literature review", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:237809

Metadata
TitleHeterotopic ossifications in patients post SARS-CoV infection: case report and literature review
Title (croatian)Heterotopične osifikacije nakon SARS-CoV infekcije: prikaz slučaja i pregled literature
AuthorPeter Papič
MentorTomislav Smoljanović (mentor)
Committee memberTomislav Smoljanović (predsjednik povjerenstva)
Committee memberDomagoj Delimar (član povjerenstva)
Committee memberIvan Bohaček (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract
Heterotopic ossification (HO) is defined as the ectopic formation of lamellar bone in extraskeletal tissues. It can cause pain, redness, warmth, swelling, and limited range of motion at the affected site, significantly reducing patients' quality of life. HO most commonly occurs after mechanical trauma, burns, traumatic brain injury, and various orthopedic surgical procedures. Why HO occurs hasn’t been proven, but it has been hypothesized to be connected with an increase in inflammatory markers causing the differentiation of mesenchymal stem cells into osteoprogenitor cells. Since the beginning of the global coronavirus disease 2019 (COVID-19) pandemic officially declared by the World Health Organization on May 11th, 2020, numerous authors have reported a possible correlation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and increased risk of formation of HO. A report of a patient who developed HO in hip and knee regions following severe SARS-CoV-2 infection is provided together with a literature review related to the subject. This literature review included 42 patients who experienced HO after being admitted to the intensive care unit and receiving mechanical ventilation due to SARS-CoV-2 infection. Out of the 32 patients whose HO locations were identified, the hip joint was affected in 22 patients (68.8%), making it the most prevalent area affected. Surgical excision of the HO was reported for 13 patients. For the remaining patients, conservative, non-surgical treatments were utilized, which resulted in significant relief. A common denominator between these cases of ectopic bone growth after COVID-19 infection was analysed. It is considered that the occurrence of HO following SARS-CoV-2 infection is due to the increase in inflammatory markers connected to prolonged hospitalization in the intensive care unit, lack of mobility and mechanical ventilation, and associated metabolic disturbances, but confirmation requires additional research.
Abstract (croatian)
Heterotopična ossifikacija (HO) definirana je kao ektopična formacija laminarne kosti u ekstra-skeletnim tkivima. To može uzrokovati bol, crvenilo, toplinu, oticanje i ograničen raspon pokreta u zahvaćenom području, značajno smanjujući kvalitetu života bolesnika. Najčešće se HO javlja nakon mehaničke traume, opeklina, traumatske ozljede mozga i raznih ortopedskih kirurških postupaka. Zašto se HO javlja nije dokazano, ali se hipotetiziralo da je povezano s povećanjem upalnih markera koji uzrokuju diferencijaciju mezenhimalnih matičnih stanica u osteoprogenitorske stanice. Od službenog proglašenja globalne koronavirus bolesti 2019 (eng. coronavirus disease 2019 (COVID-19)) pandemije od strane Svjetske zdravstvene organizacije 11. svibnja 2020. godine, nekoliko autora izvijestilo je o mogućoj povezanosti između teškog akutnog respiratornog sindroma uzrokovanog koronavirusom 2 (eng. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) infekcije i povećanog rizika formacije HO. Prikazan je slučaj bolesnika u kojega su se razvile HO u području kukova i koljena nakon preboljenja teškog oblika SARS-CoV-2 infekcije zajedno s pregledom literature iz te tematike. Ovaj pregled literature obuhvatio je 42 pacijenta koji su razvili HO nakon što su bili primljeni na intenzivnu njegu i primali mehaničku ventilaciju zbog infekcije SARS-CoV-2. Zglob kuka bio je najčešće pogođeno područje od strane HO, zahvaćajući 22 od ukupno 32 (68,8%) pacijenata čije su lokacije HO-a bile prikazane. Kirurško uklanjanje HO učinjeno je kod 13 pacijenta. Za preostale pacijente primjenjivane su konzervativne, nekirurške terapije koje su rezultirale značajnim olakšanjem. Analiziran je zajednički uzročnik nastanka HO nakon COVID-19 infekcije. Smatra se da je pojavnost HO nakon SARS-COV-2 infekcije povezana s povećanjem upalnih čimbenika tijekom produljene hospitalizacije u jedinici intenzivne njege, nedostane pokretljivosti i mehaničke ventilacije s povezanim metaboličkim poremećajima, ali potvrda tih sumnji zahtijeva dodatna istraživanja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:237809
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-01 11:41:12