prikaz prve stranice dokumenta Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb
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master's thesis
Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:777383
Pour Modjib, Kiarash
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Pour Modjib, K. (2023). Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:777383

Pour Modjib, Kiarash. "Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:777383

Pour Modjib, Kiarash. "Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:777383

Pour Modjib, K. (2023). 'Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb', Master's thesis, University of Zagreb, School of Medicine, accessed 06 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:777383

Pour Modjib K. Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:105:777383

K. Pour Modjib, "Retrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:777383

Metadata
TitleRetrospective analysis of patients with thrombotic thrombocytopenic purpura treated at the University Hospital Center Zagreb
Title (croatian)Retrospektivna analiza bolesnika s trombotičnom trombocitopeničnom purpurom liječenim u KBC Zagreb
AuthorKiarash Pour Modjib
MentorDražen Pulanić (mentor)
Committee memberDražen Pulanić (predsjednik povjerenstva)
Committee memberNadira Duraković (član povjerenstva)
Committee memberMartina Lovrić Benčić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic hemolytic anemia with thrombocytopenia caused by low ADAMTS13. There is the acquired and the hereditary type. In the acquired type there is immune-mediated ADAMTS13 deficiency, caused by autoantibodies against ADAMTS13, and the hereditary TTP is caused by compound heterozygote or homozygote mutations in ADAMTS13 gene. The clinical picture of acute TTP presents with microangiopathic hemolytic anemia, thrombocytopenia, usually mild kidney impairment, neurological symptoms and sometimes fever. Since TTP is an emergency, which can end up in stroke, multiorgan failure and death, quick diagnosis and intervention is needed. In this work retrospective analysis of 10 patients with TTP who were followed up in the Hematology outpatient clinic of the University Hospital Center Zagreb from 2016-2022 was performed. Two patients had hereditary and 8 patients had acquired TTP. This work confirmed already existing facts about the disease and presents results about age and gender distribution, clinical symptoms, laboratory parameters, etiological factors, treatment outcome and long – term sequelae in these patients.
Abstract (croatian)
Trombotična trombocitopenijčna purpura (TTP) je mikroangiopatska hemolitička anemija s trombocitopenijom uzrokovana niskim ADAMTS13. Postoji stečeni i nasljedni tip. U stečenom tipu postoji imunološki posredovani nedostatak ADAMTS13, uzrokovan autoantitijelima protiv ADAMTS13, a nasljedni TTP uzrokovan je složenim heterozigotnim ili homozigotnim mutacijama u genu ADAMTS13. Klinička slika akutne TTP manifestira se mikroangiopatskom hemolitičkom anemijom, trombocitopenijom, obično blagim oštećenjem bubrega, neurološkim simptomima i ponekad vrućicom. Budući da je TTP hitan slučaj, koji može završiti moždanim udarom, multiorganskim zatajenjem i smrću, potrebna je brza dijagnoza i intervencija. U ovom radu provedena je retrospektivna analiza 10 bolesnika s TTP-om koji su praćeni u hematološkoj ambulanti KBC-a Zagreb od 2016.-2022. Dva bolesnika imala su nasljednu, a 8 bolesnika stečenu TTP. Ovim radom potvrđene su već postojeće činjenice o bolesti te su prikazani rezultati o dobnoj i spolnoj distribuciji, kliničkim simptomima, laboratorijskim parametrima, etiološkim čimbenicima, ishodu liječenja i dugoročnim posljedicama u ovih bolesnika.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:777383
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-01 11:57:50