Liver metastases (LM) are a heterogenous group of secondary neoplasms that originate from various primary sites but share a common pathway of metastasizing. From a surgical perspective, colorectal carcinoma (CRC) is the most significant tumor that disseminates to the liver, due to a high global burden of this disease, but also because of a significant potential for survival with a successful hepatic resection. Neuroendocrine tumors, and noncolorectal, nonneuroendocrine tumors also commonly disseminate to the liver and have potential for surgical treatment. A retrospective study of patients who underwent hepatic resection of liver metastases was conducted at the Department of Surgery of the University Hospital Center Zagreb. The goal of the study was to compare surgical strategies for patients with liver metastases who were treated at the University Hospital Center Zagreb from January 1st, 2017, until December 31st, 2021. The highest proportion of liver resections (75,8%) was for colorectal cancer liver metastases. Patients were diagnosed with LM either metachronously or synchronously, and with a right- or left-sided primary tumor. Resection margins and the embryologic origin of the primary tumor demonstrated the clearest impact on survival, while resections of synchronous and metachronous LM showed comparable survival rates.