prikaz prve stranice dokumenta Osteochondral transplantation in the knee
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master's thesis
Osteochondral transplantation in the knee
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:585909
Tsadik, Coral
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Tsadik, C. (2023). Osteochondral transplantation in the knee (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:585909

Tsadik, Coral. "Osteochondral transplantation in the knee." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:585909

Tsadik, Coral. "Osteochondral transplantation in the knee." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:585909

Tsadik, C. (2023). 'Osteochondral transplantation in the knee', Master's thesis, University of Zagreb, School of Medicine, accessed 29 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:585909

Tsadik C. Osteochondral transplantation in the knee [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 April 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:585909

C. Tsadik, "Osteochondral transplantation in the knee", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:585909

Metadata
TitleOsteochondral transplantation in the knee
Title (croatian)Transplantacija koštano hrskavičnog presatka u koljenu
AuthorCoral Tsadik
MentorMislav Jelić (mentor)
Committee memberMislav Jelić (predsjednik povjerenstva)
Committee memberDomagoj Delimar (član povjerenstva)
Committee memberTomislav Đapić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract
Osteochondral transplantation is a promising surgical technique for the treatment of chondral defects in the knee joint, particularly in young, active individuals. The procedure involves the transfer of healthy osteochondral tissue from a donor site to the damaged area, facilitating the restoration of joint function and pain relief. Chondral defects, often a result of trauma or degenerative joint diseases, are prevalent in the 15-55 age group, with epidemiological data indicating a higher incidence among athletes and physically active individuals (1). In cases where conservative management and other surgical interventions have proven ineffective, osteochondral transplantation offers a viable alternative. The current gold standard for osteochondral transplantation is the osteochondral autograft transfer system (OATS), which utilizes autologous grafts harvested from a low-weight-bearing area of the patient's own knee. This technique boasts several advantages, including reduced immunogenicity and optimal graft integration. However, it is limited by the availability of donor tissue and potential donor site morbidity. Despite these limitations, osteochondral transplantation has demonstrated success in terms of pain relief, functional improvement, and overall patient satisfaction. Further research is needed to optimize patient selection criteria, refine surgical techniques, and explore the potential of allografts and tissue-engineered constructs to overcome current challenges in the field.
Abstract (croatian)
Osteohondralna transplantacija je obećavajuća kirurška tehnika za liječenje hondralnih defekata u zglobu koljena, osobito kod mladih i aktivnih osoba. Postupak uključuje prijenos zdravog osteohondralnog tkiva s donorskog mjesta na oštećeno područje, čime se olakšava ponovna uspostava funkcije zgloba i ublažavanje boli. Hondralni defekti, koji se često pojavljuju kao posljedica traume ili degenerativnih bolesti zglobova, prevladavaju u dobnoj skupini od 15 do 55 godina, a epidemiološki podaci ukazuju na veću učestalost među sportašima i tjelesno aktivnim osobama (1). U slučajevima u kojima su se konzervativno liječenje i druge kirurške intervencije pokazale neučinkovitima, osteohondralna transplantacija nudi održivu alternativu. Trenutačni zlatni standard za osteohondralnu transplantaciju je sustav za prijenos osteohondralnog autotransplantata (OATS), koji koristi autologne transplantate prikupljene iz nenosivog dijela pacijentovog vlastitog koljena. Ova tehnika ima nekoliko prednosti, uključujući smanjenu imunogenost i optimalnu integraciju presatka. Međutim, ograničen je dostupnošću donorskog tkiva i mogućim morbiditetom na mjestu presađivanja. Unatoč ovim ograničenjima, osteohondralna transplantacija je pokazala uspjeh u smislu ublažavanja boli, funkcionalnog poboljšanja i ukupnog zadovoljstva pacijenata. Potrebna su daljnja istraživanja kako bi se optimizirali kriteriji odabira pacijenata, usavršile kirurške tehnike i istražio potencijal alografta i konstrukta napravljenih tkivnim inženjeringom za prevladavanje trenutnih izazova na terenu.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:585909
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-01 12:23:11