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master's thesis
The role of limosilactobacillus reuteri strains on human health
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:228147
Bošnjak, Adam
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bošnjak, A. (2023). The role of limosilactobacillus reuteri strains on human health (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:228147

Bošnjak, Adam. "The role of limosilactobacillus reuteri strains on human health." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:228147

Bošnjak, Adam. "The role of limosilactobacillus reuteri strains on human health." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:228147

Bošnjak, A. (2023). 'The role of limosilactobacillus reuteri strains on human health', Master's thesis, University of Zagreb, School of Medicine, accessed 28 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:228147

Bošnjak A. The role of limosilactobacillus reuteri strains on human health [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 April 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:228147

A. Bošnjak, "The role of limosilactobacillus reuteri strains on human health", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:228147

Metadata
TitleThe role of limosilactobacillus reuteri strains on human health
Title (croatian)Uloga sojeva bakterije limosilactobacillus reuteri na ljudsko zdravlje
AuthorAdam Bošnjak
MentorMihaela Perić (mentor)
Committee memberMihaela Perić (predsjednik povjerenstva)
Committee memberFran Borovečki (član povjerenstva)
Committee memberNino Sinčić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract
In recent years the human gastrointestinal microbiota has proven to play a critical role in host health and disease. The majority of human microbiota resides in the large intestine and is composed of a diverse array of microorganisms, including bacteria, fungi, and archaea. Among these, Limosilactobacillus reuteri (formerly known as Lactobacillus reuteri), a gram-positive, heterofermentative lactic acid bacterium has gained attention as a probiotic due to its potential health benefits. Several strains of L. reuteri have been identified, each with its unique set of functional genes contributing to its probiotic effects. The beneficial properties include gastrointestinal microbiota modulation, pathogen colonization resistance, cobalamin synthesis, as well as positive endocrine, musculoskeletal, integumentary effects, anti-inflammatory, and neurodevelopmental effects. Many chronic diseases have been associated with states of microbiota imbalance called dysbiosis. In contrast to the conventional pharmaceutical management of chronic diseases, probiotics such as L. reuteri could serve as important treatment options to rehabilitate perturbed microbial ecosystems and its functionally active metabolites, thus improving the safety and efficacy of current clinical practices. With more data gathered, L. reuteri could become a valuable tool for treating chronic conditions and restoring human health.
Abstract (croatian)
Posljednjih godina istraživanja su pokazala da mikrobiota probavnog trakta igra ključnu ulogu u zdravlju i bolesti ljudi. Većina ljudske mikrobiote nalazi se u debelom crijevu i sastoji se od raznolikog niza mikroorganizama, uključujući bakterije, gljivice, i arheje. Među njima se ističe gram-pozitivna, heterofermentativna bakterija mliječne kiseline Limosilactobacilllus reuteri (ranije poznata kao Lactobacillus reuteri) koja je privukla pozornost kao probiotik zbog svojih potencijalnih zdravstvenih koristi. Identificirano je nekoliko sojeva L. reuteri, koji svaki sa svojim jedinstvenim skupom funkcionalnih gena pridonose specifičnim probiotičkim učincima. Tu spadaju modulacija gastrointestinalne mikrobiote, otpornost na kolonizaciju patogena, sinteza kobalamina te pozitivni učinci na endokrini, mišićno-koštani, pokrovni i imuni sustav te na neurorazvoj. Mnoge kronične bolesti povezuju se sa stanjima neravnoteže mikrobiote koja se nazivaju disbiozom. Za razliku od konvencionalnog farmaceutskog liječenja kroničnih bolesti, probiotici poput L. reuteri mogli bi poslužiti kao važne terapijske opcije u oporavku narušenih mikrobnih ekosustava i njegovih funkcionalno aktivnih metabolita te tako unaprijediti sigurnost i učinkovitost trenutnih kliničkih praksi. S više prikupljenih podataka, L. reuteri bi mogao postati vrijedan alat za liječenje kroničnih stanja kao i za unapređenje ljudskog zdravlja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:228147
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-04 11:14:27