prikaz prve stranice dokumenta Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain
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Scientific paper - Original scientific paper
Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain
Scientific Reports, 13 (2023), 1; 8539. https://doi.org/10.1038/s41598-023-35515-8
Srakočić, Sanja; Gorup, Dunja; Kutlić, Dominik; Petrović, Ante; Tarabykin, Victor; Gajović, Srećko

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Srakočić, S., Gorup, D., Kutlić, D., Petrović, A., Tarabykin, V. & Gajović, S. (2023). Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain. Scientific Reports, 13. (1). doi: 10.1038/s41598-023-35515-8

Srakočić, Sanja, et al. "Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain." Scientific Reports, vol. 13, no. 1, 2023. https://doi.org/10.1038/s41598-023-35515-8

Srakočić, Sanja, Dunja Gorup, Dominik Kutlić, Ante Petrović, Victor Tarabykin and Srećko Gajović. "Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain." Scientific Reports 13, no. 1 (2023). https://doi.org/10.1038/s41598-023-35515-8

Srakočić, S., et al. (2023) 'Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain', Scientific Reports, 13(1). doi: 10.1038/s41598-023-35515-8

Srakočić S, Gorup D, Kutlić D, Petrović A, Tarabykin V, Gajović S. Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain. Scientific Reports [Internet]. 2023 May 26 [cited 2024 November 26];13(1). doi: 10.1038/s41598-023-35515-8

S. Srakočić, D. Gorup, D. Kutlić, A. Petrović, V. Tarabykin and S. Gajović, "Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain", Scientific Reports, vol. 13, no. 1, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:967438. [Accessed: 26 November 2024]

Metadata
Title (english)Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain
AuthorSanja Srakočić
AuthorDunja Gorup
AuthorDominik Kutlić
AuthorAnte Petrović
AuthorVictor Tarabykin
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
The aim of this study was to characterize expression of corticogenesis-related transcription factors BCL11B and SATB2 after brain ischemic lesion in the adult mice, and to analyze their correlation to the subsequent brain recovery. Ischemic brain lesion was induced by transient middle cerebral artery occlusion followed by reperfusion, and the animals with ischemic lesion were compared to the sham controls. Progression of the brain damage and subsequent recovery was longitudinally monitored structurally, by magnetic resonance imaging, and functionally, by neurological deficit assessment. Seven days after the ischemic injury the brains were isolated and analyzed by immunohistochemistry. The results showed higher expression in the brain of both, BCL11B and SATB2 in the animals with ischemic lesion compared to the sham controls. The co-expression of both markers, BCL11B and SATB2, increased in the ischemic brains, as well as the co-expression of BCL11B with the beneficial transcriptional factor ATF3 but not its co-expression with detrimental HDAC2. BCL11B was mainly implicated in the ipsilateral and SATB2 in the contralateral brain hemisphere, and their level in these regions correlated with the functional recovery rate. The results indicate that the reactivation of corticogenesis-related transcription factors BCL11B and SATB2 is beneficial after brain ischemic lesion.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewNo peer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 13, no. 1, 8539
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-023-35515-8
URN:NBNurn:nbn:hr:105:967438
Publication2023-05-26
Document URLhttps://www.nature.com/articles/s41598-023-35515-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-19 06:57:04