Prostate cancer represents a significant health issue, both globally and in Croatia. Factors such as older age, family history of the disease, and African ancestry contribute to an increased risk of the disease. To detect the disease in its early stages, screening with prostate-specific antigen (PSA) is used, although this can lead to over-diagnosis and treatment of clinically insignificant prostate carcinoma. For patients with suspected prostate cancer, the evaluation includes PSA determination, digital rectal examination, magnetic resonance imaging to detect suspicious areas, but only a prostate biopsy provides a definitive diagnosis. Patients with localized and locally advanced stages of the disease are offered options such as active surveillance, external radiotherapy, brachytherapy, and radical prostatectomy. In cases of metastatic cancer, hormonal therapy is the primary treatment method, supplemented with docetaxel and/or androgen receptor-targeted agents (ARTA). When the cancer becomes resistant to hormonal therapy, known as castration-resistant prostate cancer, there are several therapeutic approaches, such as sequential drug therapy that we now introduce in the hormone-sensitive phase of the disease, the introduction of cabazitaxel, olaparib, or radium-223. Due to the numerous options in treating prostate cancer and the heterogeneity of the disease itself, the patient should be managed by a multidisciplinary team composed of specialists in urology, radiation oncology, medical oncology, pathology, anesthesiology, radiology, and nuclear medicine. The primary goal of their collaboration is the precise staging of the disease to select an appropriate therapeutic strategy, taking into account the patient's specifics. This approach achieves an individualized treatment perspective leading to better clinical outcomes and a better patient experience.