Doctors are continuously trying to reduce infertility in the modern world. Since there are various causes of infertility, infertility approach protocols have been created for each individual cause. Clinical research and experience of treating infertility of a certain etiology is extremely important in order to improve future treatment. This paper summarizes approach and guidelines about treatment of infertility in patients with hypogonadotropic hypogonadism. Hypogonadotropic hypogonadism is a condition of reproductive system and one of the cause of infertility with low gonadotropins, hypoestrogenism, anovulation and amenorrhea. Hypogonadotropic hypogonadism can have organic or functional origin, as well as it can be congenital and acquired. During the diagnostic procedure, it is important to exclude life-threatening conditions such as hypothalamic and pituitary tumors. Lifestyle changes are the first treatment option of functional hypogonadotropic hypogonadism and are also a preparation for pregnancy. If lifestyle changes are not sufficient, ovulation is being induced by gonadotropins or GnRH pumps. ovulation induction, hypogonadotropic hypogonadism, amenorrhea, GnRH pump, FSH, LH, IVFIf these methods do not result in pregnancy or if the couple has another cause of infertility as well, the next possibility is assisted reproductive technology. Since isolated hypothalamic amenorrhea is infrequent indication for IVF, further clinical research is needed.