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master's thesis
Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:708872
Kakarigi, Luka
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kakarigi, L. (2023). Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:708872

Kakarigi, Luka. "Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:708872

Kakarigi, Luka. "Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:708872

Kakarigi, L. (2023). 'Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:708872

Kakarigi L. Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:708872

L. Kakarigi, "Razlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:708872

Metadata
TitleRazlike u ishodima liječenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom
Title (english)Open vs laparoscopic adrenalectomy for localized adrenocortical carcinoma
AuthorLuka Kakarigi
MentorDarko Kaštelan (mentor)
Committee memberTina Dušek (predsjednik povjerenstva)
Committee memberMartina Lovrić Benčić (član povjerenstva)
Committee memberDarko Kaštelan (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2023-05-31, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj istraživanja bio je usporediti razlike u dugoročnim ishodima ljiečenja otvorenom i laparoskopskom adrenalektomijom kod bolesnika s lokaliziranim adrenokortikalnim karcinomom (ACC). Ovo retrospektivno istraživanje obuhvatilo je 46 bolesnika s ACC ENSAT stadijem I-III, od čega je 23 bilo podvrgnuto otvorenoj (OA skupina) i 23 laparoskopskoj adrenalektomiji (LA skupina). Ishodi liječenja koji su bili analizirani su preživljenje bez povratka bolesti (RFS) i ukupno preživljenje (OS) te njihove razlike među grupama bolesnika liječenih OA i LA. Bolesnici OA skupine imali su veće tumore (120 [70-250] mm naspram 75 [26-110] mm; P < 0.001), viši Ki-67 indeks (16 [1-65] % naspram 10 [1-25] %; P = 0.04) i uznapredovaliji stadij bolesti (P = 0.01) u odnosu na bolesnike LA skupine. Medijan praćenja bolesnika OA skupine bio je 51 (12-174) mjesec, a bolesnika LA skupine 53 (5-127) mjeseca. U osmero bolesnika (5 OA i 3 LA) bolest je recidivirala, a šestero bolesnika (3 OA i 3 LA) je tijekom perioda praćenja umrlo. Nisu nađene razlike u RFS i OS između OA i LA skupine. Ovo istraživanje pokazalo je kako je, po pitanju RFS i OS, LA primjerena terapijska opcija u bolesnika s lokaliziranim ACC bez invazija ekstra-adrenalnog tkiva. Ipak, naši su rezultati ograničeni na referentne centre s velikim iskustvom u liječenju bolesnika s ACC i stoga nisu nužno primjenjivi na centre koji imaju manje iskustva u liječenju ovih bolesnika.
Abstract (english)
The purpose of the study was to compare the long-term outcomes of patients with localized adrenocortical carcinoma (ACC) subjected to open vs laparoscopic surgery. This retrospective study included 46 patients with the ACC ENSAT stage I- stage III of whom 23 underwent open surgery (OA group), whereas 23 were subjected to laparoscopic adrenalectomy (LA group). The main outcomes analysed in the study were differences between the OA and LA groups in recurrence-free survival (RFS) and overall survival (OS). Patients in OA group had larger tumours (120 [70-250] mm vs 75 [26-110] mm; P < 0.001), higher Ki-67 index (16 [1-65] % vs 10 [1-25] %; P = 0.04) and higher disease stage (P = 0.01) compared with patients in the LA group. The median duration of follow-up for patients that underwent OA and LA was 51 (12-174) and 53 (5-127) months, respectively. Eight patients (5 OA and 3 LA) experienced recurrence of disease, whereas six patients (3 OA and 3 LA) died during follow-up. No differences in RFS and OS were found between patinets who underwent open or laparoscopic surgery. The study demonstrated that in patients with localized ACC and without invasion of extra-adrenal tissue, LA is a plausible treatment option in terms of RFS and OS. However, our results are limited to referral centres with large experience in management of patients with ACC and therefore may not necessarily apply to non-specialized centres.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:708872
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-25 09:43:17