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master's thesis
Komplikacije monokorijalne blizanačke trudnoće
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:642582
Kovačić, Trpimir
University of Zagreb
School of Medicine
Department of Gynecology and Obstetrics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Kovačić, T. (2023). Komplikacije monokorijalne blizanačke trudnoće (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:642582

Kovačić, Trpimir. "Komplikacije monokorijalne blizanačke trudnoće." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:642582

Kovačić, Trpimir. "Komplikacije monokorijalne blizanačke trudnoće." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:642582

Kovačić, T. (2023). 'Komplikacije monokorijalne blizanačke trudnoće', Master's thesis, University of Zagreb, School of Medicine, accessed 29 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:642582

Kovačić T. Komplikacije monokorijalne blizanačke trudnoće [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 April 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:642582

T. Kovačić, "Komplikacije monokorijalne blizanačke trudnoće", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:642582

Metadata
TitleKomplikacije monokorijalne blizanačke trudnoće
Title (english)Complications of monochorionic twins pregnancy
AuthorTrpimir Kovačić
MentorTrpimir Goluža (mentor)
Committee memberVesna Elveđi Gašparović (predsjednik povjerenstva)
Committee memberDinka Pavičić Baldani (član povjerenstva)
Committee memberTrpimir Goluža (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Blizanačka trudnoća označava prisutnost dvaju fetusa tijekom iste trudnoće i predstavlja stanja više stope neonatalnog mortaliteta i morbiditeta u odnosu na jednoplodne trudnoće. Blizanačke trudnoće dijele se prema korionicitetu na dva tipa: bikorionske i monokorionske. Monokorijalne trudnoće stanja su povećane učestalosti specifičnih komplikacija u odnosu na bikorionske trudnoće. Komplikacije monokorijalne trudnoće nastaju kao posljedica jedinstvene vaskularizacije monokorijalne placente i prisutnosti vaskularnih anastomoza preko kojih se ostvaruje izmjena krvi između blizanaca. Sindromi jedinstveni navedenom tipu trudnoća su sindrom blizanačke transfuzije (TTTS), povratna arterijska perfuzija blizanaca (TRAP) i sindrom anemije i policitemije blizanaca (TAPS). Najčešća među navedenim komplikacijama je TTTS - stanje neuravnoteženoga protoka između blizanaca s visokom stopom mortaliteta bez liječenja. TRAP je najteža komplikacija monokrijalne trudnoće, a očituje se postojanjem nevijabilnoga akardijskog fetusa i morfološki normalno razvijenog „pumpajućeg“ fetusa. TAPS je prepoznatljiv kao kronična anemija u „darivatelja“ i policitemija u „primatelja“ . Iako za svaki od sindroma ne postoji optimalan terapijski pristup, pravovremena dijagnoza i provedba preporučenih postupaka liječenja ključni su za sprečavanje intrauterine smrti jednog ili obaju fetusa.
Abstract (english)
Twin pregnancy is a state that represents coexistence of two fetuses during the same pregnancy and is connected with a higher rate of neonatal mortality and morbidity compared to singleton pregnancy. By the chorionicity, twin pregnancies are divided into two types: monochorionic and bichorionic. Monochorionic twin pregnancy is a condition of higher risk for specific complications than in dichorionic ones. Complications of monochorionic twin pregnancy occur due to unique vascularization of monochorionic placenta and presence of vascular anastomosis which allow blood transfer between two fetuses. Syndromes that are specific for those pregnancies are: Twin to Twin Transfusion Syndrome (TTTS), Twin Reversed Arterial Perfusion (TRAP) and Twin Anemia Polycythemia Syndrome (TAPS). TTTS is the most common complication. It is a condition of unbalanced blood flow between twins and if left untreated mortality rate is high. TRAP is the most severe condition of all monochorionic complications. It presents as presence of unviable acardiac fetus and morphologically developed pumping twin. TAPS manifests as chronic anemia in donor twin and polycythemia in recipient. Although, a perfect therapeutic approach does not exist, timely diagnosis and intervention are crucial for prevention of intrauterine demise of one or both twins.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:105:642582
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-25 11:48:05