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master's thesis
Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:332442
Lazibat, Karla
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Lazibat, K. (2023). Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19 (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:332442

Lazibat, Karla. "Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:332442

Lazibat, Karla. "Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:332442

Lazibat, K. (2023). 'Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19', Master's thesis, University of Zagreb, School of Medicine, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:332442

Lazibat K. Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19 [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:105:332442

K. Lazibat, "Pušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:332442

Metadata
TitlePušenje i ishodi liječenja bolesnika hospitaliziranih zbog COVID-19
Title (english)Smoking and clinical outcomes of patients hospitalized for COVID-19
AuthorKarla Lazibat
MentorMarko Lucijanić (mentor)
Committee memberRajko Kušec (predsjednik povjerenstva)
Committee memberMarko Jakopović (član povjerenstva)
Committee memberMarko Lucijanić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2023-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj ovog istraživanja bio je ustanoviti utjecaj pušenja na klinički ishod hospitaliziranih pacijenata oboljelih od COVID-19 bolesti. Retrospektivno smo analizirali podatke registra bolesnika hospitaliziranih zbog COVID-19 u Kliničkoj bolnici Dubrava u Zagrebu u periodu od 3/2020 do 6/2021. Prema pušačkom statusu, podijelili smo ispitanike u 3 skupine: aktivni pušači, bivši pušači i nepušači. Odredili smo nepovoljne kliničke ishode tijekom hospitalizacije: smrt, potreba za liječenjem mehaničkom ventilacijom, potreba za liječenjem u jedinci intenzivnog liječenja, venske tromboembolije, arterijske tromboze, veliko krvarenje i bakterijemija. Aktivno pušenje u odnosu na nepušenje bilo je statistički značajno povezano s mlađom dobi, muškim spolom, češćim prisustvom hiperlipoproteinemije, debljine, KOPB-a, koronarne bolesti i periferne arterijske bolesti (P<0.05 za sve analize). Aktivno pušenje bilo je statistički značajno povezano s većim rizikom arterijskih tromboza uz COVID-19 infekciju (prilagođeni OR 1.75 (1.15-2.64), P=0.009) i većim rizikom bakterijemije (prilagođeni OR 1.58 (1.14-2.19), P=0.005), dok je bivše pušenje bilo povezano s većim rizikom bakterijemije (OR 1.68 (1.22-2.31), P=0.001). Aktivno i bivše pušenje u odnosu na nepušenje nisu bili značajno povezani s mortalitetom, potrebom za mehaničkom ventilacijom, potrebom za liječenjem u jedinici intenzivnog liječenja, s pojavom venskih tromboembolija i velikog krvarenja u prilagođenim analizama (P>0.05). Rezultati ovog istraživanja pokazuju da pušači oboljeli od COVID-19 imaju veći rizik za nastanak komplikacija (arterijska tromboza i bakterijemija) u odnosu na nepušače te su češće opterećeni specifičnim komorbiditetima koji doprinose nepovoljnom kliničkom ishodu. Ovo istraživanje potvrđuje da je pušenje negativan čimbenik u razvoju i ishodu kliničke slike COVID-19 infekcije.
Abstract (english)
The aim of this study was to determine the influence of smoking on clinical outcomes in patients hospitalized for COVID-19. The data was retrospectively analyzed from the register of patients hospitalized due to COVID-19 at the Dubrava Clinical Hospital in Zagreb in the period from March 2020 to June 2021. According to smoking status, the patients were divided into 3 groups: active smokers, ex-smokers and non-smokers. Negative clinical outcomes during hospitalization were determined: death, mechanical ventilation, treatment in the intensive care unit, venous thromboembolism, arterial thrombosis, major hemorrhage and bacteremia. Active smoking compared to non-smoking was statistically significantly associated with younger age, male sex, more frequent presence of hyperlipoproteinemia, obesity, COPD, coronary disease and peripheral arterial disease (P<0.05 for all analyses). Active smokers had statistically significantly higher risk of arterial thrombosis (adjusted OR 1.75 (1.15-2.64), P=0.009) and a higher risk of bacteremia (adjusted OR 1.58 (1.14-2.19), P=0.005). Ex-smokers had statistically higher risk of bacteremia (OR 1.68 (1.22-2.31), P=0.001). Active and former smoking compared to non-smoking were not significantly associated with mortality, need for mechanical ventilation, treatment in the intensive care unit, or occurrence of venous thromboembolism and major bleeding in adjusted analyses (P>0.05). The results of this study show that smokers suffering from COVID-19 have a higher risk of developing complications (arterial thrombosis and bacteremia) compared to non-smokers. They are also often burdened with specific comorbidities that contribute to an unfavorable clinical outcome. This research suggests that smoking is a negative prognostic factor in COVID-19 patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:332442
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-26 09:18:07