Vitiligo is a depigmentation disorder which affects the skin. It is estimated that it affects between 0.5 and 2% of population. It is a complex disease and both environment and genetics play a role in its development. Today vitiligo is considered to be an autoimmune disease in which there is an autoimmune destruction of melanocytes which results in depigmentation of the affected skin. There are many different theories about the development of depigmented lesions. Any theory alone is not enough to explain this complicated condition and all theories are still being discussed. It can usually be diagnosed during a physical exam with dermoscopy. Vitiligo can be divided into two big groups: segmental and nonsegmental, which can be further divided into smaller subgroups. Although it used to be seen as a merely cometic issue, it is known that it can have an impact on patient's life quality, and it can be the cause of depression and anxiety. Vitiligo can be treated using topical and systemic medications, phototherapy, photochemotherapy, laser, surgical techniques, camouflage techniques and depigmentation of the surrounding skin. All patients should be offered psychological support. The first line of treatment are usually topical medications, which include topical corticosteroids and calcineurin inhibitors. Systemic corticosteroids can be used in more severe vitiligo cases, but we should be careful about systemic side effects which they can cause. The most common phototherapy method is NB-UVB, while photochemotherapy (PUVA) is used less because of its dose dependent carcinogenic effect. Laser treatment, which directly targets the depigmentation, can also be used. Those treatment methods can be combined. Stable vitiligo patches, which did not respond to previously mentioned treatment methods, are suitable for surgical treatment, which can be divided into tissue transplantation and cells transplantation methods. If most of the skin surface is affected, there are methods for depigmentation of the surrounding skin. Lesions can be covered up using camouflage techniques, which include make-up and self-tanning products. Intensive research is being done on medications targeting JAK kinases and proinflammatory cytokines.