Depression is a common mental disorder that affects millions of people worldwide, with an increasing number of individuals affected. The etiology of depression is complex, and there are numerous biological and psychosocial theories that explain its onset. In today's world, over 90% of people are engaged in some form of spiritual or religious practice, and the majority of individuals report that their religiosity and spirituality serve as a source of comfort in difficult life situations and in coping with illness. In recent years, there has been increasing interest in spirituality and its role in the treatment of psychiatric disorders. While there are traditional medical approaches for treatment of depression, many experts believe that psychiatrists should be more sensitive to the spiritual and religious needs of patients, and that it would be desirable to involve them in the treatment process with their consent. There are numerous studies that talk about the possible positive effects of spirituality and religiosity on the treatment and faster recovery of patients suffering from a depressive disorder. Similarly, individuals who consider spirituality as a significant aspect of their lives have a lower risk of experiencing suicidal thoughts and suicide attempts. Every individual has a spiritual dimension that also affects overall health. Spiritual therapy addresses the spiritual dimension of a person and can have a positive impact on the course of treatment for patients with depressive disorders. Hagiotherapy is a therapeutic method for healing the spiritual dimension of a person, which can provide a sense of meaning and purpose in the life of patients suffering from depressive disorder, as well as support and hope, thus positively influencing the course of treatment. Spirituality and religiosity are significant aspects of most people's lives, and further research is needed to explore their role in the treatment of depression and other mental disorders, as well as physical illnesses.