The new 11th Edition of the International Classification of Diseases and Related Health problems were electronically known to the audience by Internet in the year 2019. It introduces numerous changes in the diagnoses related to sexual health. The sexual health is a key element of overall health and wellbeing that is often stigmatized by society. This paper explores the changes in the new classification and compares them to the previous edition (ICD-10) as well as to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The new classification recognizes sexual health conditions as a distinct part of medicine and separates them from mental disorders. In the new chapter, we find sexual dysfunctions, sexual pain disorders and gender incongruence. The new classification introduces a new descriptive category named etiological considerations in sexual dysfunction and sexual pain disorders, as well as temporal and situational qualifiers. Compulsive sexual behavior and paraphilic disorders remain in the chapter of mental disorders, while sexual orientation can no longer be considered a disorder. The possibility of linking diagnoses in the new classification brings an improvement in diagnosing and it will provide better medical care. It also paves a path for the development of a new specialization in Croatian medicine. The new classification provides the foundation for better understanding and treatment of conditions related to sexual health and creates a holistic approach to patients, giving the matter careful consideration for multidisciplinary nature of sexual health conditions.