Diabetes mellitus (DM) is a growing public health problem which, due to severe complications, represents one of the biggest financial burdens on the health care system. Macrovascular complications are characterized by the appearance of atherosclerosis, the more severe forms of which, such as peripheral arterial disease or non-traumatic amputations of the lower limbs, are more susceptible to these patients. The distribution of peripheral arterial disease (PAD) in DM patients more often involves more distal arteries, and other treatment challenges include motor, sensory and autonomic neuropathy, the combination of which predisposes to the development of diabetic foot. Diabetic foot is a complex syndrome characterized by a foot ulcer and numerous comorbidities such as infection and ischemia. In addition to having a poor prognosis, diabetic foot syndrome has an extremely negative impact on the loss of quality of life and independence, as it exposes patients to the risk of lower limb amputations. The priorities of ulcer treatment consist of prevention and early identification of patients, therefore, for every patient suspected of diabetic ulcer, it is necessary to do an extensive diagnostic workup that includes procedures from physical examination and non-invasive hemodynamic tests to the use of angiography as the gold standard of visualization of the vascular system. Treatment decisions are based on the performed diagnostics and classification systems, and they need to be individualized for each patient. Therapeutic measures are diverse and include a spectrum from pharmacological treatment, surgical approach with debridement to alternative and adjuvant methods, but in saving limbs from amputation, the mainstay of treatment is revascularization. The choice of open or endovascular revascularization procedure is based on the cross section of the GLASS and WIfI stages of the limb, and the existence of an adequate autologous vein. Although most therapeutic approaches fall within the scope of a vascular surgeon, overall treatment requires a multidisciplinary team consisting of different specialists able to manage all potential complications of diabetic ulcer and provide the patient with the best possible approach to deal with this demanding disease.