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doctoral thesis
Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:829231
Bogdanić, Maja
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Bogdanić, M. (2023). Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:829231

Bogdanić, Maja. "Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:829231

Bogdanić, Maja. "Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj." Doctoral thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:829231

Bogdanić, M. (2023). 'Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj', Doctoral thesis, University of Zagreb, School of Medicine, accessed 28 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:829231

Bogdanić M. Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 April 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:829231

M. Bogdanić, "Prevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:829231

Metadata
TitlePrevalencija i molekularno-epidemiološke značajke neuroinvazivnih arbovirusnih infekcija u Republici Hrvatskoj
Title (english)Prevalence and molecular epidemiology of neuroinvasive arboviral infections in Croatia
AuthorMaja Bogdanić
MentorTatjana Vilibić Čavlek (mentor)
MentorVladimir Savić (komentor)
Committee memberNataša Beader (predsjednik povjerenstva)
Committee memberBranko Kolarić (član povjerenstva)
Committee memberJasmina Vraneš (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-11-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Public Health
Universal decimal classification
(UDC)		614 - Public health and hygiene. Accident prevention
Abstract
Iako većinom prolaze asimptomatski, u nekih se bolesnika arbovirusne infekcije očituju teškom kliničkom slikom neuroinvazivne bolesti. Ovo istraživanje uključilo je 492 bolesnika s neuroinvazivnom infekcijom oboljelih tijekom četiri uzastopne sezone prijenosa arbovirusa (2017.-2020. godine). Istražena je učestalost virusa krpeljnog encefalitisa (KMEV), West Nile (WNV), Usutu (USUV), Toscana (TOSV), Tahyna orthobunyavirusa (TAHV) i Bhanja bandavirusa (BHAV) određivanjem virusne RNK/specifičnih protutijela. Arbovirusna etiologija dokazana je u 118 (23,9%) bolesnika. U ukupnom broju bolesnika s dokazanom etiologijom, najučestaliji uzročnik je bio WNV (52,5%), zatim KMEV (38,9%), a sporadično su dokazani USUV (2,6%), TOSV (2,6%), TAHV (1,7%) te BHAV (1,7%). Nadalje, NT protutijela na TAHV i BHAV dokazana su u serumu 10,3% te 20,6% bolesnika s nedokazanom etiologijom. Neuroinvazivne arbovirusne infekcije bile su češće u muškarca u odnosu na žene (62,7% naspram 37,3%). Više od polovice oboljelih (55,9%) bilo je u dobi iznad 60 godina. U kliničkoj slici dominirao je meningitis (57,8%) i meningoencefalitis (34,5%). Uočena je karakteristična sezonska pojavnost arbovirusnih infekcija (travanj-listopad). Dokazani arbovirusi bili su geografski rasprostranjeni u kontinentalnim županijama, osim TOSV-a dokazanog na području priobalja. Filogenetska analiza pokazala je prisutnost europskog podtipa KMEV, WNV linije 2 te USUV europske linije 2. Definiranje prevalencije i molekularno-epidemioloških značajki dokazanih arbovirusa predstavlja izvorni znanstveni doprinos epidemiologiji arbovirusnih infekcija.
Abstract (english)
Although mostly asymptomatic, arboviral infections are presented with a severe clinical presentation of a neuroinvasive illness in some patients. A total of 492 patients with neuroinvasive infections were tested for the presence of arboviruses during four consecutive seasons (2017-2020). The prevalence of tick-borne encephalitis (TBEV), West Nile (WNV), Usutu (USUV), Toscana (TOSV), Tahyna orthobunyavirus (TAHV), and Bhanja bandavirus (BHAV) was analyzed by detection of viral RNA/antibodies. Neuroinvasive arboviral infections were confirmed in 118 (23.9%) patients. WNV and TBEV were the most common arboviruses detected in 52.5% and 38.9% of patients, whereas USUV (2.6%), TOSV (2.6%), TAHV (1.7%) and BHAV (1.7%) were detected sporadically. In addition, TAHV and BHAV NT antibodies were documented in serum samples of 10.3% and 20.6% of patients with unknown etiology. Males were infected more commonly (62.7%) than females (37.3%). Patients in the age group >60 years were most commonly affected (55.9%). The majority of patients presented with meningitis (57.7%) and meningoencephalitis (34.5%). Arboviruses showed seasonal distribution (April-October). Infections were detected in continental counties, whereas TOSV was detected at the Croatian littoral. Sequenced strains showed the circulation of the TBEV European subtype, WNV lineage 2, and USUV Europe 2 lineage. Defining the prevalence and molecular epidemiology represents an original scientific contribution to the epidemiology of arboviral infections.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:829231
ProjectNumber: IP-2016-06-7456
Title: Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Acronym: CRONEUROARBO
Leader: Tatjana Vilibić Čavlek
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
ProjectNumber: 653316
Title: European Virus Archive goes global
Acronym: EVAg
Jurisdiction: eu
Funder: EC
Funding stream: H2020
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent100 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-11-16 09:10:06