Premedication is a vital part of the surgery patient preparation. Premedication during preoperative management involves the usage of the drug up to 2 hours before anesthesia. The goals of the pharmacological premedications are anxiolysis, sedation, analgesia, amnesia, decrease in salivation, reducing gastric volume and and increase the pH in gastric contents, antiemetic effect, preventing the reflex responses of the autonomic nervous system, prophylaxis of allergic reaction, infection prevention and prevention of deep vein thrombosis. The need for taking the medication is based on anesthesia assesment of the individual patient, and in view of the situation and the need the application of the drug is regulated. Premedication should not worsen the patient's current condition, and the choice of drug ,dose, time and route of administration should be adapted to the particular patient. Preoperative patient preparation includes risk assessment of the surgical procedure which the patient undergoes. Appropriate preoperative patient preparation is one of the key factors that contribute to the reduction of perioperative mortality. Providing adequate support to individual organ systems allows for better control of the patient's vital functions during surgery, a rapid recovery from anesthesia, postoperative pain control and faster patient recovery.