Modern psychiatry is increasingly opening up to the appreciation and importance of spirituality with a holistic approach to the patient by providing comprehensive health care in an attempt to treat mental disorders. Such spirituality-imbued care opens up new insights in recognizing and creating a credible and original meaning of life whose primary purpose is to help, treat and connect with others. Given the indicated relevance, a review of professional papers shows an increasingly intense focus on appreciating religious beliefs and respecting and enabling the realization of religious customs of patients in a clinical setting. The advent of clinical instruments, including FICA, HOPE and OASIS, has made it possible to assess the spiritual needs of patients in order to achieve an optimal therapeutic outcome. In accordance with the implementation of integral health care and respect for human holistic needs, from the very beginning, nursing care is based on the skills that unite human's physical, spiritual, mental and emotional levels, which is supported by various theories of nursing throughout history. Attentive care and spiritual support that contribute to recovery were advocated by theorists Florence Nightingale, Callista Roy, Margaret Jean Harman Watson and Joyce Travelbee, with an emphasis on promoting interpersonal relationships imbued with empathy and warmth. The distinctiveness of an effective implementation of spiritual care in the nursing care of persons with mental disorders requires from nurses and technicians an exceptional empathetic character predisposition and ethics of virtues, based on compassion, patience and willingness to serve the person entirely. The aim of this paper is to show the holistic needs of a person in a health setting and how by including spirituality in nursing care, a person with a mental disorder manages to cope with anxiety, fears, stress, depression and existential suffering by building patience and encouraging hope in recovery or an easier disease tolerance.