prikaz prve stranice dokumenta Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience
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Scientific paper - Original scientific paper
Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience
European Journal of Cardio-Thoracic Surgery, 63 (2023), 5; ezad105. https://doi.org/10.1093/ejcts/ezad105
Verzelloni Sef, Alessandra; Jaggar, Siân I; Trkulja, Vladimir; Alonso-Gonzalez, Rafael; Šef, Davorin; Turina, Marko I

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Verzelloni Sef, A., Jaggar, S. I., Trkulja, V., Alonso Gonzalez, R., Šef, D. & Turina, M. I. (2023). Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience. European Journal of Cardio-Thoracic Surgery, 63. (5). doi: 10.1093/ejcts/ezad105

Verzelloni Sef, Alessandra, et al. "Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience." European Journal of Cardio-Thoracic Surgery, vol. 63, no. 5, 2023. https://doi.org/10.1093/ejcts/ezad105

Verzelloni Sef, Alessandra, Siân I Jaggar, Vladimir Trkulja, Rafael Alonso Gonzalez, Davorin Šef and Marko I Turina. "Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience." European Journal of Cardio-Thoracic Surgery 63, no. 5 (2023). https://doi.org/10.1093/ejcts/ezad105

Verzelloni Sef, A., et al. (2023) 'Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience', European Journal of Cardio-Thoracic Surgery, 63(5). doi: 10.1093/ejcts/ezad105

Verzelloni Sef A, Jaggar SI, Trkulja V, Alonso Gonzalez R, Šef D, Turina MI. Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience. European Journal of Cardio-Thoracic Surgery [Internet]. 2023 May 01 [cited 2024 May 03];63(5). doi: 10.1093/ejcts/ezad105

A. Verzelloni Sef, S. I. Jaggar, V. Trkulja, R. Alonso Gonzalez, D. Šef and M. I. Turina, "Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience", European Journal of Cardio-Thoracic Surgery, vol. 63, no. 5, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:212038. [Accessed: 03 May 2024]

Metadata
Title (english)Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience
AuthorAlessandra Verzelloni Sef
AuthorSiân I Jaggar
AuthorVladimir Trkulja
AuthorRafael Alonso-Gonzalez
AuthorDavorin Šef
AuthorMarko I Turina
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Objectives: Studies concerning factors associated with long-term outcomes in adult congenital heart disease (ACHD) patients after infective endocarditis (IE) are scarce, while IE-related mortality in these patients remains a burden. We evaluated the factors associated with long-term survival in ACHD patients admitted for IE. Methods: We performed a retrospective single-centre study of all ACHD patients admitted for IE to a tertiary cardiothoracic centre between 1999 and 2015. Underlying ACHD, detailed echocardiographic and clinical data, surgical treatment and long-term follow-up were analysed. Results: We identified 151 ACHD patients admitted due to 176 episodes IE with 30-day, 6-month and 1-, 5- and 10-year survival of 95.4%, 92.7%, 92.7%, 84.7% and 75.6%, respectively. In a multivariable analysis, adjusted estimated probability of death was consistently higher after an IE episode among patients with complex as compared to simple/moderate ACHD: 10.6% vs 2.4% at 30 days, 15.0% vs 3.4% at 6 months and 1 year, 30.4% vs 7.8% at 5 years and 44.9% vs 13.1% at 10 years. Risk of death was higher among patients with prosthetic valve in comparison with those without (risk ratios 1.73-1.92). Surgical treatment was required in 76 (43.2%) episodes with 30-day mortality of 3.9%. Risk of death appeared to be lower than in the conservatively treated subgroup (risk ratios 0.71-0.78). Conclusions: We demonstrated satisfactory long-term survival in ACHD patients who were treated for IE in a tertiary cardiothoracic centre. Early mortality tended to be lower in the surgically treated subgroup. Factors negatively associated with long-term survival were complex ACHD and presence of prosthetic valve.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Cardio-Thoracic Surgery
Numberingvol. 63, no. 5, ezad105
e-ISSN1873-734X
DOIhttps://doi.org/10.1093/ejcts/ezad105
URN:NBNurn:nbn:hr:105:212038
Publication2023-05-01
Document URLhttps://academic.oup.com/ejcts/article/doi/10.1093/ejcts/ezad105/7083437
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-09 09:27:52