prikaz prve stranice dokumenta Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
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Scientific paper - Original scientific paper
Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
Croatian Medical Journal, 64 (2023), 5; 320-328. https://doi.org/10.3325/cmj.2023.64.320
Fučić, Aleksandra; Knežević, Jelena; Krasić, Jure; Polančec, Denis; Sinčić, Nino; Sindičić Dessardo, Nada; Starčević, Mirta; Guszak, Vedrana; Ceppi, Marcello; Bruzzone, Marco

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Fučić, A., Knežević, J., Krasić, J., Polančec, D., Sinčić, N., Sindičić Dessardo, N. ... Bruzzone, M. (2023). Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth. Croatian Medical Journal, 64. (5), 320-328. doi: 10.3325/cmj.2023.64.320

Fučić, Aleksandra, et al. "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth." Croatian Medical Journal, vol. 64, no. 5, 2023, pp. 320-328. https://doi.org/10.3325/cmj.2023.64.320

Fučić, Aleksandra, Jelena Knežević, Jure Krasić, Denis Polančec, Nino Sinčić, Nada Sindičić Dessardo, Mirta Starčević, Vedrana Guszak, Marcello Ceppi and Marco Bruzzone. "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth." Croatian Medical Journal 64, no. 5 (2023): 320-328. https://doi.org/10.3325/cmj.2023.64.320

Fučić, A., et al. (2023) 'Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth', Croatian Medical Journal, 64(5), pp. 320-328. doi: 10.3325/cmj.2023.64.320

Fučić A, Knežević J, Krasić J, Polančec D, Sinčić N, Sindičić Dessardo N, and sur.. Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth. Croatian Medical Journal [Internet]. 2023 October 31 [cited 2024 May 03];64(5):320-328. doi: 10.3325/cmj.2023.64.320

A. Fučić, et al., "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth", Croatian Medical Journal, vol. 64, no. 5, pp. 320-328, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:490836. [Accessed: 03 May 2024]

Metadata
Title (english)Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
AuthorAleksandra Fučić
AuthorJelena Knežević
AuthorJure Krasić
AuthorDenis Polančec
AuthorNino Sinčić
AuthorNada Sindičić Dessardo
AuthorMirta Starčević
AuthorVedrana Guszak
AuthorMarcello Ceppi
AuthorMarco Bruzzone
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Aim: To compare interleukin-2 levels (IL-2) and IL-2 gene site 1 methylation levels between preterm newborns (PN) and full-term newborns (FN) and investigate their association with the environmental exposure of their mothers during pregnancy. Methods: IL-2 and IL-2 gene site 1 methylation levels were assessed in 50 PN and 56 FN. Newborns' mothers filled in questionnaires about their living and occupational environments, habits, diets, and hobbies. Results: The mothers of PN were significantly more frequently agrarian/rural residents than the mothers of FN. PN had significantly higher IL-2 levels, and significantly lower methylation of IL-2 gene site 1 levels than FN. Conclusion: IL-2 levels, hypomethylation of the IL-2 gene site 1, and the mother's rural residence (probably due to pesticide exposure) were predictive biomarkers for preterm birth. For the first time, we present the reference values for the methylation of IL-2 gene site 1 in PN and FN, which can be used in the clinical setting and biomonitoring.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 64, no. 5, pp. 320-328
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2023.64.320
URN:NBNurn:nbn:hr:105:490836
Publication2023-10-31
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668044/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-01-09 12:38:32